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单词 pms2
释义

PMS2


PMS2

A gene on 7p22.2 that encodes a mismatch repair enzyme that scans newly replicated DNA for errors and repairs mismatched bases in the DNA. The enzyme forms a heterodimer with MLH1, and this complex interacts with other complexes bound to mismatched bases.
Molecular pathology
Defects in PMS2 cause hereditary nonpolyposis colorectal cancer type 4, Turcot syndrome and supratentorial primitive neuroectodermal tumours.

PMS2


AcronymDefinition
PMS2Postmeiotic Segregation Increased, S. Cerevisiae, 2
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更新时间:2024/12/23 21:31:01