anthrax lethal factor

anthrax lethal factor

(an'thraks lē'thăl fak'tŏr), A protein secreted by Bacillus anthracis, that selectively induces apoptosis of activated macrophages by cleaving the amino-terminal extension of mitogen-activated protein kinase kinases (MKKs). This action may allow the bacteria to avoid detection by the host's innate immune system.