vicious viscous hypothesis
vicious viscous hypothesis
Kinetic hypothesis Hematology A hypothesis that attempts to explain the pathogenesis of the microvascular occlusions typical of sickle cell anemia; according to VVH, the ↑ in blood viscosity caused by the relatively inelastic sickled RBCs, slows blood flow inthe microcirculation; this slowing results in relative hypoxia, which favors further sickling of upstream RBCs, resulting in vascular occlusion and infarction