Putnam-Dana syndrome


degeneration

 [de-gen″ĕ-ra´shun] deterioration; change from a higher to a lower form, especially change of tissue to a lower or less functionally active form. When there is chemical change of the tissue itself, it is true degeneration; when the change consists in the deposit of abnormal matter in the tissues, it is infiltration. adj., adj degen´erative.caseous degeneration caseation (def. 2).cerebromacular degeneration (cerebroretinal degeneration) 1. degeneration of brain cells and of the macula retinae, as occurs in tay-sachs disease.2. any lipidosis with cerebral lesions and degeneration of the retinal macula.3. any form of neuronal ceroid-lipofuscinosis.colloid degeneration degeneration with conversion of the tissues into a gelatinous or gumlike material.cystic degeneration degeneration with formation of cysts.fatty degeneration deposit of fat globules in a tissue.fibroid degeneration degeneration of a leiomyoma" >leiomyoma with subsequent fibrosis" >fibrosis.hepatolenticular degeneration Wilson's disease.hyaline degeneration a regressive change in cells in which the cytoplasm takes on a homogeneous, glassy appearance; also used loosely to describe the histologic appearance of tissues.hydropic degeneration a form in which the epithelial cells absorb much water.lattice degeneration of retina a frequently bilateral, usually benign asymptomatic condition, characterized by patches of fine gray or white lines that intersect at irregular intervals in the peripheral retina, usually associated with numerous, round, punched-out areas of retinal thinning or retinal holes.macular degeneration see macular degeneration.macular degeneration, congenital see stargardt's disease.macular degeneration, Stargardt's stargardt's disease.mucoid degeneration degeneration with deposit of myelin and lecithin in the cells.mucous degeneration degeneration with accumulation of mucus in epithelial tissues.myofibrillar degeneration damage to selective cardiac cells when surrounding interstitial cells, nerves, and capillaries remain viable.myxomatous degeneration mucous degeneration.spongy degeneration of central nervous system (spongy degeneration of white matter) Canavan disease.subacute combined degeneration of spinal cord degeneration of both the posterior and lateral columns of the spinal cord, producing various motor and sensory disturbances; it is due to vitamin B12 deficiency and is usually associated with pernicious anemia. Called also Lichtheim's or Putnam-Dana syndrome.wallerian degeneration fatty degeneration of a nerve fiber that has been severed from its nutritive source.Zenker's degeneration Zenker's necrosis.

sub·a·cute com·bined de·gen·er·a·tion of the spi·nal cord

a subacute or chronic disorder of the spinal cord, such as that occurring in certain patients with vitamin B12 deficiency, characterized by a slight to moderate degree of gliosis in association with spongiform degeneration of the posterior and lateral columns. Synonym(s): combined sclerosis, combined system disease, funicular myelitis (2) , Putnam-Dana syndrome, vitamin B12 neuropathy

sub·a·cute com·bined de·gen·er·a·tion of the spi·nal cord

(sŭb'ă-kyūt' kŏm-bīnd' dĕ-jen'ĕr-ā'shŭn spī'năl kōrd) A disorder of the spinal cord, such as that occurring in vitamin B12 deficiency, characterized by gliosis with spongiform degeneration of the posterior and lateral columns.
Synonym(s): Putnam-Dana syndrome, vitamin B12 neuropathy.

Dana,

Charles L., U.S. neurologist, 1852-1935. Dana operation - section of posterior spinal root. Synonym(s): posterior rhizotomyDana syndrome - degenerative disease of the spinal cord associated with pernicious anemia.Putnam-Dana syndrome - see under Putnam

Putnam,

James J., U.S. neurologist, 1846-1918. Putnam-Dana syndrome - subacute combined degeneration of the spinal cord.