space-occupying lesion


space-occupying lesion

Hematology A lesion that replaces BM, alters its architecture and/or depresses marrow production, resulting in myelophthisic anemia; most SOLs are due to metastases from 1º CAs of lung, breast, prostate, thyroid, adrenals, but may be due to myeloma, leukemia, lymphoma, osteosclerosis, myelofibrosis; all 3 blood cell lines are affected; immature RBCs and WBCs appear in peripheral circulation, due to irritation phenomena. See Myelofibrosis. Myelophthisic anemia