释义 |
sickling crisis sickling crisis An acute episode in homozygous sickle cell disease in which a massive breakdown of red blood cells occurs with widespread severe pain from blockage of small blood vessels by sickled red cells. Some cases involve great enlargement of the liver or spleen and gross anaemia, others may affect the lungs with severe breathlessness and pleuritic pain, or the brain causing a stroke. Skilled and energetic management in hospital is mandatory for the sickling crisis. |