abzyme

cat·a·lyt·ic an·ti·bod·y

an antibody that has been altered to give it a catalytic activity. Synonym(s): abzyme

Abzyme

Any of a number of hybrid catalytic molecules with antibody-like specificity. The hybrid is generated by combining an antibody with an enzyme; the “ab-” portion corresponds to the highly specific binding sequence, analogous to an immunoglobulin’s variable region, and the “-zyme” portion incorporates catalytic machinery. While most abzymes are synthetic and typically the antibody component is raised against a transition state analogue for the reaction to be catalysed, they may also occur in autoimmune disease, especially systemic lupus erythematosus.

abzyme

An antibody that has an enzyme-like (catalytic) action.

abzyme

a catalytic ANTIBODY, with variable regions possessing enzyme activity. An abzyme is capable of catalysing a chemical reaction by binding to and stabilizing the transition state intermediate.

单词	abzyme
释义	abzyme abzyme [′ab‚zīm] (immunology) catalytic antibody abzyme cat·a·lyt·ic an·ti·bod·y an antibody that has been altered to give it a catalytic activity. Synonym(s): abzyme Abzyme Any of a number of hybrid catalytic molecules with antibody-like specificity. The hybrid is generated by combining an antibody with an enzyme; the “ab-” portion corresponds to the highly specific binding sequence, analogous to an immunoglobulin’s variable region, and the “-zyme” portion incorporates catalytic machinery. While most abzymes are synthetic and typically the antibody component is raised against a transition state analogue for the reaction to be catalysed, they may also occur in autoimmune disease, especially systemic lupus erythematosus. abzyme An antibody that has an enzyme-like (catalytic) action. abzyme a catalytic ANTIBODY, with variable regions possessing enzyme activity. An abzyme is capable of catalysing a chemical reaction by binding to and stabilizing the transition state intermediate.
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