Theobald Smith phenomenon


The·o·bald Smith phe·nom·e·non

(thē'ō-bahld smith), a phenomenon observed in guinea pigs that had survived use for diphtheria antitoxin standardization, the animals having been rendered highly susceptible to subsequent inoculation of horse serum.

Smith,

Theobald, U.S. pathologist, 1859-1934. Theobald Smith phenomenon - guinea pigs that had survived use for diphtheria antitoxin standardization were highly susceptible to subsequent inoculation of horse serum.