phylloquinone

phyl·lo·qui·none

P5299000 (fĭl′ə-kwĭ-nōn′, -kwĭn′ōn)n. See vitamin K₁.

phylloquinone

(ˌfɪləʊkwɪˈnəʊn) n (Biochemistry) a viscous fat-soluble liquid occurring in plants: essential for the production of prothrombin, required in blood clotting. Formula: C31H46O2. Also: vitamin K1

vitamin K1

n. a yellowish, oily, viscous liquid, C₃₁H₄₆O₂, that occurs in leafy vegetables, rice, bran, and hog liver or is obtained esp. from alfalfa or putrefied sardine meat or synthesized and that promotes blood clotting by increasing the prothrombin content of the blood. Also called phylloquinone, phytonadione. [1930–35]

vitamin K2

n. a light yellow, crystalline solid, C₄₁H₅₆O₂, having properties similar to those of vitamin K₁. [1935–40]

vitamin K3

n. menadione. [1955–60]

Thesaurus

Noun

phylloquinone - a form of vitamin Kphytonadione, vitamin K1antihemorrhagic factor, naphthoquinone, vitamin K - a fat-soluble vitamin that helps in the clotting of blood

Phylloquinone

(also vitamin K₁; chemical name, 2-methyl-3-phytyl-l,4-naphthoquinone), an oil-soluble vitamin. Phylloquinone was first isolated in 1939, by P. Karrer. The vitamin is a light yellow, viscous liquid that is capable of fluorescence and is insoluble in water. Its structural formula is

Phylloquinone is synthesized in the green parts of plants and by microorganisms. In humans and other mammals, it is formed by intestinal microflora. Phylloquinone figures in the biosynthesis of certain blood-coagulation factors, namely prothrombin and factors VII, IX, and X. Like other oil-soluble vitamins, phylloquinone is a constituent of the lipids that form part of biological membranes.

A deficiency of phylloquinone in humans and animals usually derives not from an insufficiency of the vitamin in the food but rather from a disruption of the vitamin’s absorption by the walls of the intestine. The disruption can result either from disorders of the gallbladder and liver (obstructive jaundice, cirrhosis of the liver) or from overdoses of medicines that suppress intestinal microflora. Phylloquinone deficiency leads to hemorrhages and hemorrhagic diathesis, interferes with the metabolism of high-energy compounds, and lowers the activity of many enzymes. Anticoagulants of the coumarin and indandione types inhibit the biosynthesis of phylloquinone.

Phylloquinone is effective in treating those suffering from K₁, hypovitaminosis. Vicasol, an analogue of vitamin K₁ is used as an antihemorrhagic. In industry, phylloquinone is synthesized from 2-methyl-l,4-naphthoquinone and either phytol or isophytol.

REFERENCES

Lakin, K. M. Lekarstvennaia reguliatsiia svertyvaniia krovi. Moscow, 1971.
Berezovskii, V. M. Khimiia vitaminov, 2nd ed. Moscow, 1973.
Matusis, I. I. Vitaminy i antivitaminy. Moscow, 1975.

R. P. EVSTIGNEEVA

phylloquinone

phyl·lo·quin·one (K),

, phylloquinone K (fil'ō-kwin'ōn, -kwī'nōn), The major form of vitamin K found in plants isolated from alfalfa; also prepared synthetically. Synonym(s): phytomenadione, phytonadione, vitamin K1, vitamin K1

phylloquinone

(fĭl′ə-kwĭ-nōn′, -kwĭn′ōn)n. See vitamin K₁.

phyl·lo·quin·one

(filō-kwinōn) Compound isolated from alfalfa; also prepared synthetically; major form of vitamin K found in plants.
Synonym(s): vitamin K1, vitamin K1.

phylloquinone

see VITAMIN K.

Phylloquinone

An alternate name for vitamin K₁.Mentioned in: Vitamin K Deficiency

phyl·lo·quin·one

(filō-kwinōn) Major form of vitamin K found in plants isolated from alfalfa.
Synonym(s): vitamin K1.

phylloquinone

phyl·lo·qui·none

phylloquinone

vitamin K1

vitamin K2

vitamin K3

Phylloquinone

Phylloquinone

REFERENCES

phylloquinone

phyl·lo·quin·one (K),

phylloquinone

phyl·lo·quin·one

phylloquinone

Phylloquinone

phyl·lo·quin·one

phylloquinone

Synonyms for phylloquinone

noun a form of vitamin K

Synonyms

Related Words