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DictionarySeeIAEncyclopediaSeevaudoisVaughan Williams classification
Vaughan Williams classification Cardiology The system by EM Vaughan Williams, used to categorize effects of antiarrhythmics by class. See Antiarrhythmic drugs. Cf Sicilian Gambit. Vaughan Williams Classification of Antiarrhythmic Drugs Class I Sodium-channel blockers IA Moderately slow conduction, moderately prolonged duration of action potential–active in atria, ventricles; most cardiotoxic group Examples Quinidine, procainamide, diisopyramide IB Minimally slowed conduction, shortened duration of action potential–active in atria; greatest potential for proarrhythmias Examples Lidocaine, mexiletine, tocainamide, phenytoin IC Markedly slowed conduction, minimally duration of action potential–active in atria, ventricles; most effective group Examples Flecainide, encainide, propafenone, moricizine Class II Beta blockers–active in AV nodes, ventricles; virtually no proarrhythmic effect Class III Potassium-channel blockers; prolonged duration of action potential Examples Amiodarone, bretylium, sotalol, ibutilide Class IV Calcium-channel blockers–active in AV nodes; virtually no proarrhythmic effect FinancialSeeIC |