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DictionarySeepseudomonasPseudomonas aeruginosa
Pseudomonas aeruginosa[‚süd·ə‚mōn·əs ‚ar·ə·jə′nō·sə] (microbiology) An opportunistic pathogen that is the most significant cause of hospital-acquired infections, particularly in predisposed patients with metabolic, hematologic, and malignant diseases. It produces toxic factors such as lipase, esterase, lecithinase, elastase, and endotoxin, some of which may contribute to its pathogenesis. Pseudomonas aeruginosa
Pseu·do·mo·nas ae·ru·gi·no·'saa bacterial species found in soil, water, and commonly in clinical specimens (wound infections, infected burn lesions, urinary tract infections); the causative agent of blue pus; occasionally pathogenic for plants; usually causes infections in humans in whom there is a defect in host defense mechanisms. It is the type species of the genus Pseudomonas. Synonym(s): blue pus bacilluspseudomonas aeruginosa A normal soil inhabitant and human saprobe/commensal which may contaminate various solutions and fluids in a hospital, causing opportunistic infection in immunocompromised patients.
Clinical findings
Infective endocarditis in IV drug users, respiratory tract infections, urinary tract infections, bacteraemia, meningitis, “malignant” external otitis.
Management
Aminoglycosides—e.g., gentamicin, amikacin, netilmicin, tobramycin, etc.
Pathogenesis
Pseudonomas aeruginosa is both invasive and toxicogenic, and infects patients in a 3-step process:
1. Bacterial attachment and colonization—mediated by pili and antiphagocytic effects of the organism’s polysaccharide capsule;
2. Local invasion—mediated by elastase and bacterial alkaline protease; and
3. Dissemination—high-dose tobramycin delivered by aerosol is reportedly effective in patients with cystic fibrosis.Pseudomonas aeruginosa A normal soil inhabitant and human saprophyte that may contaminate various solutions in a hospital, causing opportunistic infection in weakened Pts Clinical Infective endocarditis in IVDAs, RTIs, UTIs, bacteremia, meningitis, 'malignant' external otitis Treatment Aminoglycosides–eg, gentamicin, amikacin, tobramycin, etcPseu·do·mo·nas ae·ru·gi·no·sa (sū-dō-mōnăz ē-rū-ji-nōsă) Bacterial species found in soil, water, and commonly in clinical specimens (wound infections, infected burn lesions, urinary tract infections); produces blue pus.  Psuedomonas Aeruginosa: infection of the distal footPseudomonas aeruginosaA species that produces a distinctive blue-green pigment, grows readily in water, and may cause life-threatening infections in humans, including nosocomial pneumonia, urinary tract infections, and sepsis. It may also cause folliculitis, malignant otitis externa, and skin infections in patients who have suffered burns. See: illustrationSee also: PseudomonasAcronymsSeePAEThesaurusSeePseudomonas |