azilsartan
azilsartan
(a-zill-sar-tan) azilsartan,Edarbi
(trade name)Classification
Therapeutic: antihypertensivesPharmacologic: angiotensin ii receptor antagonists
Indications
Action
Therapeutic effects
Pharmacokinetics
Time/action profile (effect on BP)
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | within 2 hr | 18 hr | 24 hr |
Contraindications/Precautions
Adverse Reactions/Side Effects
Central nervous system
- dizziness
- fatigue
- weakness
Cardiovascular
- hypotension (most frequent)
Fluid and Electrolyte
- hyperkalemia
Gastrointestinal
- diarrhea (most frequent)
- nausea
Genitourinary
- impaired renal function
Musculoskeletal
- muscle spasm
Interactions
Drug-Drug interaction
Concurrent use of potassium-sparing diuretics, potassium-containing salt substitutes, or potassium supplements may ↑ risk of hyperkalemia.↑ risk of hyperkalemia, renal dysfunction, hypotension, and syncope with concurrent use of ACE inhibitors or aliskiren ; avoid concurrent use with aliskiren in patients with diabetes or CCr <60 mL/minNSAIDs and selective COX-2 inhibitors may blunt the antihypertensive effect and ↑ the risk of renal dysfunction.↑ antihypertensive effect with other antihypertensives or diuretics.Route/Dosage
Availability
Nursing implications
Nursing assessment
- Assess BP (sitting, lying, standing) and pulse periodically during therapy.
- Monitor frequency of prescription refills to determine adherence to therapy.
- Lab Test Considerations: Monitor renal function. May cause small, reversible ↑ serum creatinine. May cause worsening renal function in patients with renal impairment. May rarely cause slight ↓ in RBC, hemoglobin and hematocrit.
- May cause low and high markedly abnormal platelet and WBC.
Potential Nursing Diagnoses
Risk for injury (Adverse Reactions)Noncompliance (Patient/Family Teaching)
Implementation
- Correct volume and salt depletion, if possible, before initiation of therapy, or start treatment at 40 mg.
- Oral: Administer once daily without regard to food.
Patient/Family Teaching
- Emphasize the importance of continuing to take as directed, even if feeling well. Take missed doses as soon as remembered if not almost before next dose; do not double doses. Medication controls but does not cure hypertension. Instruct patient to take medication at the same time each day. Warn patient not to discontinue therapy unless directed by health care professional.
- Encourage patient to comply with additional interventions for hypertension (weight reduction, low-sodium diet, smoking cessation, moderation of alcohol consumption, regular exercise, and stress management). Medication controls but does not cure hypertension.
- Instruct patient and family on proper technique for monitoring BP. Advise them to check BP at least weekly and to report significant changes.
- Caution patient to avoid sudden position changes to decrease orthostatic hypotension. Use of alcohol, standing for long periods, exercising, and hot weather may ↑ orthostatic hypotension.
- May cause dizziness. Caution patient to avoid driving and other activities requiring alertness until response to medication is known.
- Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and consult health care professional before taking any new medications, especially NSAIDs and cough, cold, or allergy medications.
- Instruct patient to notify health care professional of medication regimen before treatment or surgery.
- Advise women of childbearing age to use contraception and notify health care professional if pregnancy is planned or suspected, or if breastfeeding. Azilsartan should be discontinued as soon as possible when pregnancy is detected.
- Emphasize the importance of follow-up exams to evaluate effectiveness of medication.
Evaluation/Desired Outcomes
- ↓ in BP without excessive side effects.