pseudoephedrine hydrochloride

Contac Non Drowsy (UK), Galsud (UK), Genaphed, Kidkare Decongestant, Meltus Decongestant (UK), Non-Drowsy Sudafed Decongestant (UK), Robidrine (CA), Silfedrine Children's, Sudafed, Sudafed Children's Nasal Decongestant, Sudafed 12 Hour, Sudo-Tab, Sudodrin, SudoGest

pseudoephedrine sulfate

Drixoral Nasal Decongestant, Drixoral Non-Drowsy Formula

Pharmacologic class: Sympathomimetic

Therapeutic class: Decongestant (systemic)

Pregnancy risk category C

Action

Stimulates alpha-adrenergic receptors, causing vasoconstriction of respiratory tract; relaxes bronchial smooth muscle through beta₂-adrenergic stimulation

Availability

pseudoephedrine hydrochloride

Capsules: 60 mg

Capsules (extended-release): 120 mg, 240 mg

Capsules (soft gel): 30 mg

Oral solution: 15 mg/5 ml, 30 mg/5 ml

Syrup: 30 mg/5 ml

Tablets: 30 mg, 60 mg

Tablets (chewable): 15 mg

Tablets (extended-release): 120 mg, 240 mg

pseudoephedrine sulfate

Tablets (extended-release, film-coated): 120 mg

Indications and dosages

➣ Nasal, sinus, or eustachian tube congestion

Adults and children ages 12 and older: 60 mg P.O. q 4 to 6 hours p.r.n. (not to exceed 240 mg/day); or 120 mg (extended-release) q 12 hours or 240 mg (extended-release) q 24 hours

Contraindications

• Hypersensitivity to drug or other sympathomimetics

• Alcohol intolerance (with some liquid products)

• Hypertension

• Severe coronary artery disease

• MAO inhibitor use within past 14 days

• Children younger than age 12 (extended-release forms)

Precautions

Use cautiously in:

• hyperthyroidism, diabetes mellitus, prostatic hypertrophy, ischemic heart disease, glaucoma

• elderly patients (more sensitive to drug's CNS effects)

• pregnant or breastfeeding patients.

Administration

• Give at least 2 hours before bedtime to minimize insomnia.

Adverse reactions

CNS: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, asthenia, seizures

CV: palpitations, hypertension, tachycardia, cardiovascular collapse

GI: anorexia, dry mouth

GU: dysuria

Respiratory: respiratory difficulty

Interactions

Drug-drug. Beta-adrenergic blockers: increased pressor effects of pseudoephedrine

MAO inhibitors: hypertensive crisis

Mecamylamine, methyldopa, reserpine: decreased antihypertensive effect of these drugs

Other sympathomimetics: additive effects, greater risk of toxicity

Drug-food. Foods that acidify urine: decreased drug efficacy

Foods that alkalize urine: increased drug efficacy

Patient monitoring

• Monitor vital signs.

• Assess neurologic and cardiovascular status regularly.

Patient teaching

• Advise patient to take at least 2 hours before bedtime to reduce insomnia.

• Tell patient not to crush or break extended-release tablets or capsules.

• Advise patient to discontinue use and consult prescriber if he experiences nervousness, dizziness, or insomnia.

• Tell patient to consult prescriber before taking other over-the-counter products.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

pseu·do·e·phed·rine hy·dro·chlor·ide

(sū'dō-e-fed'rin hī'drō-klōr'īd), The naturally occurring isomer of ephedrine; a sympathomimetic amine with actions and uses similar to those of ephedrine.

pseudoephedrine hydrochloride

(soo″dō-ĕ-fĕd′rĭn) A sympathomimetic drug, an isomer of ephedrine, that has actions similar to those of ephedrine. Trade names is Sudafed.

单词	pseudoephedrine hydrochloride
释义	DictionarySeeSudafed pseudoephedrine hydrochloride pseudoephedrine hydrochloride Contac Non Drowsy (UK), Galsud (UK), Genaphed, Kidkare Decongestant, Meltus Decongestant (UK), Non-Drowsy Sudafed Decongestant (UK), Robidrine (CA), Silfedrine Children's, Sudafed, Sudafed Children's Nasal Decongestant, Sudafed 12 Hour, Sudo-Tab, Sudodrin, SudoGest pseudoephedrine sulfate Drixoral Nasal Decongestant, Drixoral Non-Drowsy Formula *Pharmacologic class:* Sympathomimetic *Therapeutic class:* Decongestant (systemic) *Pregnancy risk category C* Action Stimulates alpha-adrenergic receptors, causing vasoconstriction of respiratory tract; relaxes bronchial smooth muscle through beta₂-adrenergic stimulation Availability pseudoephedrine hydrochloride Capsules: 60 mg Capsules (extended-release): 120 mg, 240 mg Capsules (soft gel): 30 mg Oral solution: 15 mg/5 ml, 30 mg/5 ml Syrup: 30 mg/5 ml Tablets: 30 mg, 60 mg Tablets (chewable): 15 mg Tablets (extended-release): 120 mg, 240 mg pseudoephedrine sulfate Tablets (extended-release, film-coated): 120 mg Indications and dosages ➣ Nasal, sinus, or eustachian tube congestion Adults and children ages 12 and older: 60 mg P.O. q 4 to 6 hours p.r.n. (not to exceed 240 mg/day); or 120 mg (extended-release) q 12 hours or 240 mg (extended-release) q 24 hours Contraindications • Hypersensitivity to drug or other sympathomimetics • Alcohol intolerance (with some liquid products) • Hypertension • Severe coronary artery disease • MAO inhibitor use within past 14 days • Children younger than age 12 (extended-release forms) Precautions Use cautiously in: • hyperthyroidism, diabetes mellitus, prostatic hypertrophy, ischemic heart disease, glaucoma • elderly patients (more sensitive to drug's CNS effects) • pregnant or breastfeeding patients. Administration • Give at least 2 hours before bedtime to minimize insomnia. Adverse reactions CNS: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, asthenia, seizures CV: palpitations, hypertension, tachycardia, cardiovascular collapse GI: anorexia, dry mouth GU: dysuria Respiratory: respiratory difficulty Interactions Drug-drug. Beta-adrenergic blockers: increased pressor effects of pseudoephedrine MAO inhibitors: hypertensive crisis Mecamylamine, methyldopa, reserpine: decreased antihypertensive effect of these drugs Other sympathomimetics: additive effects, greater risk of toxicity Drug-food. Foods that acidify urine: decreased drug efficacy Foods that alkalize urine: increased drug efficacy Patient monitoring • Monitor vital signs. • Assess neurologic and cardiovascular status regularly. Patient teaching • Advise patient to take at least 2 hours before bedtime to reduce insomnia. • Tell patient not to crush or break extended-release tablets or capsules. • Advise patient to discontinue use and consult prescriber if he experiences nervousness, dizziness, or insomnia. • Tell patient to consult prescriber before taking other over-the-counter products. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and foods mentioned above. pseu·do·e·phed·rine hy·dro·chlor·ide (sū'dō-e-fed'rin hī'drō-klōr'īd), The naturally occurring isomer of ephedrine; a sympathomimetic amine with actions and uses similar to those of ephedrine. pseudoephedrine hydrochloride (soo″dō-ĕ-fĕd′rĭn) A sympathomimetic drug, an isomer of ephedrine, that has actions similar to those of ephedrine. Trade names is Sudafed. ThesaurusSeepseudoephedrine
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