somatostatin

so·mat·o·stat·in

S0555720 (sō-măt′ə-stăt′n, sō′mə-tə-)n. A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.

[somato(tropin) + -stat + -in.]

somatostatin

(ˌsəʊmətəˈstætɪn) n (Biochemistry) a peptide hormone that prevents the release of growth hormone from the pituitary gland[C20: from somato- + -stat + -in]

so•mat•o•stat•in

(səˌmæt əˈstæt n)

n. a polypeptide hormone, produced in the brain and pancreas, that inhibits secretion of somatotropin from the hypothalamus and inhibits insulin production by the pancreas. [1973; somato (tropin) + -stat + -in¹]

somatostatin

enUK

Somatostatin

A naturally occurring regulatory peptide that carries out numerous functions in the human body, including the inhibition of growth hormone secretion from the anterior pituitary gland. Somatostatin consists of 14 amino acids; two cysteine residues are joined by a disulfide bond so that the peptide forms a ring structure. A larger variant of this peptide, called somatostatin-28, is produced in some cells and has an additional 14 amino acids attached at the amino-terminal end of normal somatostatin (somatostatin-14).

Somatostatin acts primarily as a negative regulator of a variety of different cell types, blocking processes such as cell secretion, cell growth, and smooth muscle contraction. It is secreted from the hypothalamus into the portal circulation and travels to the anterior pituitary gland, where it inhibits the production and release of both growth hormone and thyroid-stimulating hormone. Many tissues other than the hypothalamus contain somatostatin, suggesting that this peptide has numerous roles.

Each of the functions of somatostatin is initiated by the binding of the peptide to one or more of five different cell-surface receptor proteins, thereby activating one or more intracellular G-proteins and initiating biochemical signaling pathways within the cell. See Signal transduction

Analogs of somatostatin have been synthesized that are smaller, more potent, longer-lasting, and more specific in their biological effects than natural somatostatin. Some of these analogs have become useful as drugs. See Endocrine system (vertebrate), Hormone, Neurosecretion, Pituitary gland

somatostatin

[¦sō·məd·ə′stat·ən] (biochemistry) A peptide secreted by the hypothalamus which acts primarily to inhibit the release of growth hormone from the anterior pituitary.

somatostatin

(SRIF, SS) [so″mah-to-stat´in] a cyclic tetradecapeptide hormone and neurotransmitter that inhibits the release of peptide hormones in many tissues. It is released by the hypothalamus to inhibit the release of growth hormone (GH, somatotropin) and thyroid stimulating hormone (TSH) from the anterior pituitary; it is also released by the delta cells of the islets of Langerhans in the pancreas to inhibit the release of glucagon and insulin and by the similar D cells in the gastrointestinal tract.

so·ma·to·stat·in

(sō'mă-tō-stat'in), [MIM*182450] A tetradecapeptide capable of inhibiting the release of somatotropin by the anterior lobe of the pituitary gland; somatostatin has a short half-life; it also inhibits the release of insulin, glucagon, and gastrin. Used in the treatment of acromegaly, gigantism, and pancreatic tumors. Synonym(s): growth hormone-inhibiting hormone, somatotropin release-inhibiting factor, somatotropin release-inhibiting hormone [somatotropin + G. stasis, a standing still, + -in]

somatostatin

(sō-măt′ə-stăt′n, sō′mə-tə-)n. A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin.

so·ma·to·stat·in

(sō'mă-tō-stat'in) A tetradecapeptide capable of inhibiting release of somatotropin, insulin, and gastrin.
Compare: bioregulator
Synonym(s): growth hormone-inhibiting hormone, somatotropin release-inhibiting hormone. [somato- + G. stasis, a standing still, + -in]

somatostatin

a hormone of the hypothalamus that inhibits the release of growth hormone from the pituitary gland.

so·ma·to·stat·in

(sō'mă-tō-stat'in) [MIM*182450] Tetradecapeptide capable of inhibiting release of somatotropin by anterior lobe of pituitary gland. [somatotropin + G. stasis, a standing still, + -in]

单词	somatostatin
释义	somatostatin enUK so·mat·o·stat·in S0555720 (sō-măt′ə-stăt′n, sō′mə-tə-)n. A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin. [somato(tropin) + -stat + -in.] somatostatin (ˌsəʊmətəˈstætɪn) n (Biochemistry) a peptide hormone that prevents the release of growth hormone from the pituitary gland[C20: from somato- + -stat + -in] so•mat•o•stat•in (səˌmæt əˈstæt n) n. a polypeptide hormone, produced in the brain and pancreas, that inhibits secretion of somatotropin from the hypothalamus and inhibits insulin production by the pancreas. [1973; somato (tropin) + -stat + -in¹] somatostatin enUK Somatostatin A naturally occurring regulatory peptide that carries out numerous functions in the human body, including the inhibition of growth hormone secretion from the anterior pituitary gland. Somatostatin consists of 14 amino acids; two cysteine residues are joined by a disulfide bond so that the peptide forms a ring structure. A larger variant of this peptide, called somatostatin-28, is produced in some cells and has an additional 14 amino acids attached at the amino-terminal end of normal somatostatin (somatostatin-14). Somatostatin acts primarily as a negative regulator of a variety of different cell types, blocking processes such as cell secretion, cell growth, and smooth muscle contraction. It is secreted from the hypothalamus into the portal circulation and travels to the anterior pituitary gland, where it inhibits the production and release of both growth hormone and thyroid-stimulating hormone. Many tissues other than the hypothalamus contain somatostatin, suggesting that this peptide has numerous roles. Each of the functions of somatostatin is initiated by the binding of the peptide to one or more of five different cell-surface receptor proteins, thereby activating one or more intracellular G-proteins and initiating biochemical signaling pathways within the cell. See Signal transduction Analogs of somatostatin have been synthesized that are smaller, more potent, longer-lasting, and more specific in their biological effects than natural somatostatin. Some of these analogs have become useful as drugs. See Endocrine system (vertebrate), Hormone, Neurosecretion, Pituitary gland somatostatin [¦sō·məd·ə′stat·ən] (biochemistry) A peptide secreted by the hypothalamus which acts primarily to inhibit the release of growth hormone from the anterior pituitary. somatostatin enUK somatostatin (SRIF, SS) [so″mah-to-stat´in] a cyclic tetradecapeptide hormone and neurotransmitter that inhibits the release of peptide hormones in many tissues. It is released by the hypothalamus to inhibit the release of growth hormone (GH, somatotropin) and thyroid stimulating hormone (TSH) from the anterior pituitary; it is also released by the delta cells of the islets of Langerhans in the pancreas to inhibit the release of glucagon and insulin and by the similar D cells in the gastrointestinal tract. so·ma·to·stat·in (sō'mă-tō-stat'in), [MIM182450] A tetradecapeptide capable of inhibiting the release of somatotropin by the anterior lobe of the pituitary gland; somatostatin has a short half-life; it also inhibits the release of insulin, glucagon, and gastrin. Used in the treatment of acromegaly, gigantism, and pancreatic tumors. Synonym(s): growth hormone-inhibiting hormone, somatotropin release-inhibiting factor, somatotropin release-inhibiting hormone [somatotropin + G. stasis, a standing still, + -in] somatostatin (sō-măt′ə-stăt′n, sō′mə-tə-)n. A polypeptide hormone produced chiefly by the hypothalamus that inhibits the secretion of various other hormones, such as somatotropin, glucagon, insulin, thyrotropin, and gastrin. so·ma·to·stat·in (sō'mă-tō-stat'in) A tetradecapeptide capable of inhibiting release of somatotropin, insulin, and gastrin. Compare: bioregulator Synonym(s): growth hormone-inhibiting hormone, somatotropin release-inhibiting hormone. [somato-* + G. stasis, a standing still, + -in] somatostatin a hormone of the hypothalamus that inhibits the release of growth hormone from the pituitary gland. so·ma·to·stat·in (sō'mă-tō-stat'in) [MIM182450] Tetradecapeptide capable of inhibiting release of somatotropin by anterior lobe of pituitary gland. [somatotropin* + G. stasis, a standing still, + -in] AcronymsSeeSST
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