vulvar intraepithelial neoplasia


vulvar intraepithelial neoplasia

preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1 to 3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papilloma virus infection; may progress to invasive carcinoma.

vulvar intraepithelial neoplasia

Gynecology An umbrella term for a precancerous state characterized by the presence of dysplastic cells within the vulvar epithelium, which ranges from low-grade to carcinoma in situ. See Carcinoma in situ, CIN, Intraepithelial neoplasia.

vul·var in·tra·ep·i·the·li·al ne·o·pla·si·a

(vŭl'văr in'tră-ep'i-thē'lē-ăl nē'ō-plā'zē-ă) Preinvasive squamous cell carcinoma (carcinoma in situ) limited to vulvar epithelium; like vaginal or cervical intraepithelial neoplasia, graded histologically on a scale from 1-3 or subdivided into low-grade and high-grade intraepithelial malignancy; usually related to human papillomavirus infection; may progress to invasive carcinoma.

vulvar intraepithelial neoplasia

Abbreviation: VIN
Precancerous, noninvasive lesions of the squamous epithelium of the vulva.

Symptoms

Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking.

Diagnosis

Diagnosis is made by biopsy of the lesion.

Treatment

Treatments include brief observation to see if the condition spontaneously remits, topically applied chemotherapy, laser ablation, or wide surgical excision.

 Synonym: vaginal intraepithelial neoplasiaSee also: neoplasia