proteasome

pro·te·a·some

(prō'tē-ă-sōm), Cytoplasmic organelle, composed of a cylindric core particle bound by two regulatory particles at each end, responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein's lysine residue.
See also: ubiquitin-protease pathway. [protease + -some ]

proteasome

(prō′tē-ə-sōm′)n. A cellular protein complex consisting of proteolytic enzymes that degrade endogenous proteins, especially those that are damaged, pathogenic, or no longer of use.

proteasome

, proteosome (prō′tē-ă-sōm″) An enzymatic (protease) cell organelle that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteasomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin.

Proteasome

A large, cylindrical protein complex of several sub-units, present in the cytoplasm and nucleus of all cells and an essential component in cell metabolism. The function of the proteasome is to act as a kind of shredder, degrading unwanted proteins that have been tagged for destruction with UBIQUITIN chains. It strips proteins of their ubiquitin, unfolds them and catalyzed them to peptides. Proteasomes have aroused much interest as therapeutic trargets in cancer. The proteasome 26S is involved both in the induction and repression of APOPTOSIS. See also POLYUBIQUITINATION.

单词	proteasome
释义	proteasome pro·te·a·some P5662700 (prō′tē-ə-sōm′)n. A cellular protein complex consisting of proteolytic enzymes that degrade endogenous proteins, especially those that are damaged, pathogenic, or no longer of use. [Alteration of earlier prosome (influenced by protease) : pro(grammed), from the earlier belief that proteasomes played a role in regulating messenger RNA translation + -some.] Translations протеасома proteasome proteasome [′prōd·ē·ə‚sōm] (biochemistry) A large proteolytic particle found in the cytoplasm and nucleus of all eukaryotic cells that is the site for degradation of most intracellular proteins. proteasome pro·te·a·some (prō'tē-ă-sōm), Cytoplasmic organelle, composed of a cylindric core particle bound by two regulatory particles at each end, responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein's lysine residue. See also: ubiquitin-protease pathway. [protease + -some ] proteasome (prō′tē-ə-sōm′)n. A cellular protein complex consisting of proteolytic enzymes that degrade endogenous proteins, especially those that are damaged, pathogenic, or no longer of use. proteasome , proteosome (prō′tē-ă-sōm″) An enzymatic (protease) cell organelle that degrades misfolded or damaged proteins and modulates the quantity of regulatory proteins in the cell. The breakdown of proteins by proteasomes (proteolysis) is triggered when damaged proteins are tagged by ubiquitin. Proteasome A large, cylindrical protein complex of several sub-units, present in the cytoplasm and nucleus of all cells and an essential component in cell metabolism. The function of the proteasome is to act as a kind of shredder, degrading unwanted proteins that have been tagged for destruction with UBIQUITIN chains. It strips proteins of their ubiquitin, unfolds them and catalyzed them to peptides. Proteasomes have aroused much interest as therapeutic trargets in cancer. The proteasome 26S is involved both in the induction and repression of APOPTOSIS. See also POLYUBIQUITINATION.
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