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urokinase
u·ro·ki·nase U0151100 (yo͝or′ō-kī′nās, -nāz)n. An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.urokinase (ˌjʊərəʊˈkaɪneɪz) n (Biochemistry) a biochemical catalyst present in urine and the blood streamu•ro•ki•nase (ˌyʊər əˈkaɪ neɪs, -neɪz)
n. an enzyme, present in the blood and urine of mammals, that activates plasminogen and is used medicinally to dissolve blood clots. [1955–60] Thesaurus| Noun | 1. | urokinase - protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysisplasminogen activatorpeptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis |
Translationsurokinase
urokinase[‚yu̇r·ə′kī‚nās] (biochemistry) An enzyme, present in human urine, that catalyzes the conversion of plasminogen to plasmin. urokinase
urokinase [u″ro-ki´nās] u-plasminogen activator; the term is used particularly to denote a pharmaceutical preparation of the enzyme, administered intravenously as a thrombolytic agent in the treatment of acute coronary thrombosis and acute pulmonary embolism; also used to clear intravenous catheters of obstructions composed of clotted blood or fibrin deposits.plas·min·o·gen ac·ti·va·tora proteinase converting plasminogen to plasmin by cleavage of an Arg-Val bond in the former. Synonym(s): urokinaseurokinase (yo͝or′ō-kī′nās, -nāz)n. An enzyme originally found in human urine that catalyzes the conversion of plasminogen to plasmin and is used in medicine to dissolve blood clots.Abbokinase A proprietary formulation of urokinase, a thrombolytic that activates the fibrinolysis by increasing plasmin production from plasminogen, thereby degrading fibrin clots, fibrinogen, and other clotting factors.urokinase A fibrinolytic enzyme involved in extracellular proteolysis; it is more active during cell migration and tissue remodeling, and cleaves fibronectin. See Kringle domain. Cf Streptokinase, Reteplase, tPA. plas·min·o·gen ac·ti·va·tor (plaz-min'ŏ-jen ak'ti-vā-tŏr) A proteinase that converts plasminogen to plasmin by cleavage of a single (usually Arg-Val) bond in the former. Prevents formation of fibrin clots. Alteplase and streptokinase are examples of medications that promote thrombolysis by activating plasminogen.
Synonym(s): urokinase. urokinase An enzyme found in human urine that is used as a drug to dissolve blood clots occurring within blood vessels. A PLASMINOGEN activator.plas·min·o·gen ac·ti·va·tor (plaz-min'ŏ-jen ak'ti-vā-tŏr) A proteinase that converts plasminogen to plasmin and prevents formation of fibron clots.
Synonym(s): urokinase. AcronymsSeeunknownurokinase
Related to urokinase: streptokinaseSynonyms for urokinasenoun protease produced in the kidney that converts plasminogen to plasmin and so initiates fibrinolysisSynonymsRelated Words- peptidase
- protease
- proteinase
- proteolytic enzyme
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