单词 | arthus reaction |
释义 | Arthus reactionArthus reaction[′är·thəs rē′ak·shən]Arthus reactionAr·thus re·ac·tion(ahr'tūs),See also: immune complex disease. Synonym(s): Arthus phenomenon See also: immune complex disease. Arthus reactionA local zone of necrosis seen in the skin due to a type-III hypersensitivity immune reaction, characterised by acute immune complex deposition with vasculitis secondary to injection of an antigen to which a host has previously formed high levels of circulating antibody.immune complex diseaseImmunology Any of a number of conditions—caused by circulating antigen-antibody-immune complexes, which in the face of mild antigen excess, lodge in small vessels and filtering organs of the circulation Clinical Fever, enlarged and/or tender joints, splenic congestion, proteinuria due to glomerular IC deposition, eosinophilia, hypocomplementemia, lymphadenopathy, glomerulonephritis–HTN, oliguria, hematuria, edema, skin–purpura, urticaria, ulcers, carditis, hepatitis, myositis, necrotizing vasculitis. See Immune complex.Arthus reactionArthus phenomenon, a local necrotic reaction that occurs when an ANTIGEN is injected into the skin of a person previously sensitized to it. The preformed antibody combines with the injected antigen causing a high local concentration of immune complexes and severe tissue damage. (Nicholas Maurice Arthus, French physiologist, 1862–1945).Arthus,Nicolas Maurice, French bacteriologist, 1862-1945. |
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