Tambocor
Noun | 1. | Tambocor - oral antiarrhythmic medication (trade name Tambocor) used as a last resort in treating arrhythmias; increases the risk of sudden death in heart attack patients |
单词 | tambocor | |||
释义 | Tambocor
Tambocorflecainide acetatePharmacologic class: Cardiac benzamide local anesthetic Therapeutic class: Antiarrhythmic (class IC) Pregnancy risk category C ActionInhibits fast sodium channels of myocardial cell membrane. Also slows conduction, shortens action potential, stops paroxysmal reentrant supraventricular tachycardia, and decreases conduction in accessory pathways in Wolff-Parkinson-White syndrome. AvailabilityTablets: 50 mg, 100 mg, 150 mg Indications and dosages➣ Supraventricular tachyarrhythmias (including paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation or flutter) Adults: Initially, 50 mg P.O. q 12 hours, increased by 50 mg b.i.d. q 4 days until desired response occurs or maximum daily dosage of 300 mg is reached ➣ Sustained, life-threatening ventricular tachycardia Adults: Initially, 100 mg P.O. q 12 hours, increased by 50 mg b.i.d. q 4 days until desired response occurs or maximum daily dosage of 400 mg is reached Dosage adjustment• Heart failure • Renal impairment Off-label uses• Ventricular arrhythmias • Wolff-Parkinson-White syndrome Contraindications• Hypersensitivity to drug • Preexisting atrioventricular block or right bundle-branch block • Recent MI • Cardiogenic shock PrecautionsUse cautiously in: • heart failure, renal impairment • patients taking concurrent amiodarone, beta-adrenergic blockers, disopyramide, or verapamil • pregnant or breastfeeding patients • children (safety not established). Administration• Initiate therapy only in hospital setting with trained personnel and continuous ECG monitoring. • Before giving, correct hypokalemia or hyperkalemia. • Be aware that dosage may be reduced once arrhythmias have been adequately controlled. Adverse reactionsCNS: dizziness, anxiety, fatigue, headache, depression, malaise, tremor, weakness, hypoesthesia, paresthesia CV: chest pain, palpitations, second- or third-degree heart block, heart failure, new or worsening arrhythmias EENT: blurred vision, visual disturbances, corneal deposits GI: nausea, vomiting, constipation, abdominal pain, dyspepsia, anorexia Hepatic: hepatitis Respiratory: dyspnea Skin: rash, diaphoresis Other: edema, fever InteractionsDrug-drug. Acidifying drugs: increased renal elimination, decreased efficacy of flecainide (with urine pH below 5) Alkalizing drugs: increased flecainide blood level, possible toxicity Amiodarone: doubling of flecainide blood level Beta-adrenergic blockers: increased blood levels of both drugs Beta-adrenergic blockers, disopyramide, verapamil: additive myocardial depressant effect Digoxin: 15% to 25% increase in digoxin blood level Other antiarrhythmics (including calcium channel blockers): increased risk of arrhythmias Drug-diagnostic tests. Alkaline phosphatase: increased level (with prolonged therapy) Drug-food. Foods that decrease urine pH below 5 (such as acidic juices): increased renal elimination and possibly decreased efficacy of drug Foods that increase urine рH above 7 (as in strict vegetarian diets): increased drug blood level Drug-behaviors. Smoking: increased plasma clearance and decreased efficacy of drug Patient monitoringSee Monitor ECG for worsening arrhythmias. • Measure pacing threshold 1 week before therapy starts and again after 1 week of therapy. • Monitor potassium and flecainide blood levels. • Assess respiratory status regularly. • Monitor hepatic function tests. Patient teachingSee Instruct patient to immediately report cardiac or respiratory symptoms, unusual tiredness, or yellowing of skin or eyes. • Tell patient drug may cause numbness. Advise him to avoid injury to areas with sensory impairment. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, alertness, and vision. • Advise patient to minimize GI upset by eating small, frequent servings of food and drinking adequate fluids. • Tell female patient to inform prescriber if she is pregnant or breastfeeding. • Inform patient that he'll undergo regular blood testing during therapy. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above. Tambocor(tăm′bə-kôr′)TambocorA brand name for FLECAINIDE ACETATE.Tambocor
Synonyms for Tambocor
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