单词 | primary hyperoxaluria |
释义 | primary hyperoxaluriahyperoxaluria[hi″per-ok″sah-lu´re-ah]primary hyperoxaluriaOxalosis An AR condition characterized by crystallization in tissues Clinical Calcium oxalate–CO is ↑↑↑ in urine, resulting in CO supersaturation crystalluria, stone formation, and deposition of CO in the renal parenchyma, leading to renal dysfunction and CO deposition in multiple organs–oxalosis Treatment Orthophosphate, pyridoxine Prognosis With therapy, actuarial ESRD-free survival at 20 yrs is ± 75%; sans therapy, 80% have ESRD by the 3rd decade of life; renal transplants do not survive well; liver transplants may be used to correct the enzyme defectprimary hyperoxaluria |
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