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trisomy 18
trisomy 18n. The condition of having three copies of chromosome 18 that results in a syndrome characterized by severe congenital abnormalities including craniofacial and cardiac defects, intellectual disability, and deformities of the hands and feet. Also called Edwards syndrome.EncyclopediaSeeTrisomytrisomy 18
trisomy 18n. The condition of having three copies of chromosome 18 that results in a syndrome characterized by severe congenital abnormalities including craniofacial and cardiac defects, intellectual disability, and deformities of the hands and feet. Also called Edwards syndrome.trisomy 18 Edwards syndrome A chromosome defect due to duplication of chromosome 18 Clinical Mental retardation, hypotonia, polyhydramnios, FTT, small placenta, low-birth-weight, micrognathia, ASD, VSD, PDA, horseshoe kidney, unilateral or double kidney, double ureter, inguinal or umbilical hernia, nail hypoplasia, cleft lip and palate, deformed skull, low-set malformed ears, short sternum, cryptorchidism Incidence 1:3-11,000 Prognosis Death usually by age 2ThesaurusSeetrisomy |