请输入您要查询的英文单词:

 

单词 serine
释义

serine

enUK

ser·ine

S0282000 (sĕr′ēn′)n. An amino acid, C3H7NO3, that is a common constituent of many proteins.
[ser(icin) + -ine.]

serine

(ˈsɛriːn; ˈsɪəriːn; -rɪn) n (Biochemistry) a sweet-tasting amino acid that is synthesized in the body and is involved in the synthesis of cysteine; 2-amino-3-hydroxypropanoic acid. Formula: CH2(OH)CH(NH2)COOH[C19: from sericin + -ine2]

ser•ine

(ˈsɛr in, -ɪn, ˈsɪər-)

n. a crystalline amino acid, HOCH2CH(NH2)COOH, found in many proteins and obtained by the hydrolysis of sericin. Abbr.: Ser; Symbol: S [1875–80; < German Serin (1865); see sericin, -ine2]

ser·ine

(sĕr′ēn′) A nonessential amino acid. See more at amino acid.
Thesaurus
Noun1.serine - a sweetish crystalline amino acid involved in the synthesis by the body of cysteineamino acid, aminoalkanoic acid - organic compounds containing an amino group and a carboxylic acid group; "proteins are composed of various proportions of about 20 common amino acids"
Translations

serine

enUK

serine

(sĕr`ēn), organic compound, one of the 20 amino acidsamino acid
, any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur. These compounds are the building blocks of proteins.
..... Click the link for more information.
 commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein. It is not essential to the human diet, since it can be synthesized in the body from other metabolites, including glycineglycine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Glycine is the only one of these amino acids that is not optically active, i.e., it does not have d- and
..... Click the link for more information.
. Serine is important in metabolism in that it participates in the biosynthesis of purinespurine,
type of organic base found in the nucleotides and nucleic acids of plant and animal tissue. The German chemist Emil Fischer did much of the basic work on purines and introduced the term into the chemical literature in the early 20th cent.
..... Click the link for more information.
 and pyrimidinespyrimidine
, type of organic base found in certain coenzymes and in the nucleic acids of plant and animal tissue. The three major pyrimidines of almost universal distribution in living systems are cytosine, thymine, and uracil.
..... Click the link for more information.
, cysteinecysteine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of mammalian protein.
..... Click the link for more information.
, tryptophantryptophan
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein.
..... Click the link for more information.
 (in bacteria), and a large number of other metabolites. When incorporated into the structure of enzymes, serine often plays an important role in their catalytic function. It has been shown to occur in the active sites of chymotrypsinchymotrypsin
, proteolytic, or protein-digesting, enzyme active in the mammalian intestinal tract. It catalyzes the hydrolysis of proteins, degrading them into smaller molecules called peptides. Peptides are further split into free amino acids.
..... Click the link for more information.
, trypsintrypsin,
enzyme that acts to degrade protein; it is often referred to as a proteolytic enzyme, or proteinase. Trypsin is one of the three principal digestive proteinases, the other two being pepsin and chymotrypsin.
..... Click the link for more information.
, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Without the esterase activity that usually destroys acetylcholineacetylcholine
, a small organic molecule liberated at nerve endings as a neurotransmitter. It is particularly important in the stimulation of muscle tissue. The transmission of an impulse to the end of the nerve causes it to release neurotransmitter molecules onto the surface of
..... Click the link for more information.
 as soon as it performs its function, dangerously high levels of this neurotransmitter build up, quickly resulting in convulsions and death. Serine was first obtained from silk protein, a particularly rich source, in 1865; its structure was established in 1902.

Serine

 

(also, α-amino-β-hydroxypropionic acid), HOCH2CH(NH2)COOH, a naturally occurring amino acid. Serine exists in two optically active forms, namely, the L and D forms, and in the racemic, or DL, form. Practically all proteins contain L-serine. The proteins of silk are especially rich in serine; fibroin contains up to 16 percent, and sericin up to <0 percent. Serine was isolated from sericin in 1865 by the German chemist E. Cramer. Phosphoesters of serine also enter into the composition of proteins. Serine is a replaceable amino acid; its precursor in biosynthesis by living organisms is D-3-phosphoglyceric acid, an intermediate product of glycolysis. In cells, serine participates in the biosynthesis of glycine, sulfur-containing amino acids (methionine, cysteine), and tryptophan, as well as of ethanolamine and sphingolipids. It serves as a source for a monocarbon fragment (conversion to glycine with the participation of tetrahydrofolic acid), which plays an important role in the biosynthesis of choline and purines:

Serine + Tetrahydrofolic acid → Glycine + N5, N10-methylene-tetrahydrofolic acid

Upon the decomposition of serine in organisms, pyruvic acid is formed, which is introduced into the tricarboxylic acid cycle by means of conversion into acetyl coenzyme A. The catalytic function of a series of enzymes (chymotrypsin, trypsin, bacterial proteases, esterases, phosphorylase, phosphoglucomutase, alkaline phosphatase) derives from the reactivity of the hy-droxyl group of the serine residue, which forms part of the active site of these enzymes. Reactions of the enzymes of the serine group include the hydrolysis of peptides, amides, and the esters of carboxylic acids and the transfer of the residue of phosphoric acid. The antibiotics cycloserine and azaserine are derivatives of serine.

REFERENCE

Lehninger, A. Biokhimiia. Moscow, 1974. (Translated from English.)

E. N. SAFONOVA

serine

[′se‚rēn] (biochemistry) C3H7O3N An amino acid obtained by hydrolysis of many proteins; a biosynthetic precursor of several metabolites, including cysteine, glycine, and choline.

serine

enUK

serine

 [sēr´ēn] a naturally occurring, nonessential amino acid, used as a dietary supplement, in biological studies and tests, and in culture media.

ser·ine (S, Ser),

(ser'ēn), 2-Amino-3-hydroxypropanoic acid; the l-isomer is one of the amino acids occurring in proteins.

serine

(sĕr′ēn′)n. An amino acid, C3H7NO3, that is a common constituent of many proteins.

SERPING1

A gene on chromosome 11q12-q13.1 that encodes a highly glycosylated plasma protein which regulates the complement cascade by inhibiting activated C1r and C1s, thereby preventing complement activation.
Molecular pathology
C1-INH/SERPING1 deficiency is associated with hereditary angioneurotic oedema (HANE).

ser·ine

(S) (sĕr'ēn) One of the amino acids occurring in proteins.

serine

A non-essential amino acid found as a component of most proteins. It is a precursor of choline, glucine, cysteine and pyruvate. Serine is present in most diets but most of the body serine is synthesized.
SerineFig. 282 Serine . Molecular structure.

serine (S, Ser)

one of 20 AMINO ACIDS common in proteins. It has a polar ‘R’ group structure and is soluble in water. See Fig. 282 . The ISOELECTRIC POINT of serine is 5.7.

ser·ine

(sĕr'ēn) One of the amino acids occurring in proteins.
FinancialSeeSerAcronymsSeeSER

serine

enUK
Related to serine: Amino acids, threonine
  • noun

Words related to serine

noun a sweetish crystalline amino acid involved in the synthesis by the body of cysteine

Related Words

  • amino acid
  • aminoalkanoic acid
随便看

 

英语词典包含2567994条英英释义在线翻译词条,基本涵盖了全部常用单词的英英翻译及用法,是英语学习的有利工具。

 

Copyright © 2004-2022 Newdu.com All Rights Reserved
更新时间:2025/2/24 2:37:30