biogenic amine hypothesis

The theory that defects in the physiology and metabolism of biogenic amines, especially catecholamines (noradrenaline/norepinephrine and dopamine) and an indoleamine (serotonin), are pathogenetically linked to certain psychiatric illnesses, especially depression.
The BAH arose from the discovery that monoamine oxidase inhibitors and some tricyclic drugs had mood-elevating properties, and had a dramatic effect on brain monoamine functions; that phenothiazines inhibit cerebral dopamine activity further support this theory and suggest a link between a disorder of dopamine metabolism and schizophrenia.

单词	biogenic amine hypothesis
释义	DictionarySeehypothesis biogenic amine hypothesis biogenic amine hypothesis [¦bī·ō¦jen·ik ′a·mēn hī‚päth·ə·səs] (psychology) The hypothesis that abnormalities in the physiology and metabolism of biogenic amines are involved in the development of certain psychiatric illnesses. biogenic amine hypothesis biogenic amine hypothesis The theory that defects in the physiology and metabolism of biogenic amines, especially catecholamines (noradrenaline/norepinephrine and dopamine) and an indoleamine (serotonin), are pathogenetically linked to certain psychiatric illnesses, especially depression. The BAH arose from the discovery that monoamine oxidase inhibitors and some tricyclic drugs had mood-elevating properties, and had a dramatic effect on brain monoamine functions; that phenothiazines inhibit cerebral dopamine activity further support this theory and suggest a link between a disorder of dopamine metabolism and schizophrenia. LegalSeeHypothesis
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