T gene


T gene

A genes on chromosome 6q27 that encodes brachyury, an embryonic nuclear transcription factor that effects transcription of genes required for mesoderm formation and differentiation, and mediates epithelial-mesenchymal transition. It is localised to notochord-derived cells.
Molecular pathology
Brachyury is the definitive diagnostic marker of chordoma; it is overexpressed in various cancers and promotes invasion.