anorexia-cachexia

anorexia-cachexia

 a systemic response to cancer occurring as a result of metabolites which may be produced by the tumor cells and released into the blood stream, stimulating the satiety center in the hypothalamus and producing appetite loss, gross alterations of metabolic patterns, and a profound systemic confusion which may result in further anorexia. This leads to malnutrition, weight loss, muscular weakness, and a negative nitrogen balance that contributes to the development of cachectic wasting.