释义 |
Smurf-1 Smurf-1 Smad ubiqiutination regulatory factor 1. An E3 ubiquitin ligase that participates in a cascade of ubiquitin transfer reactions, targeting R-Smad1 and R-Smad5 for ubiquitination and proteosomal degradation; it appears to specifically control BMP signalling and reduce intracellular levels of R-Smads independent of BMP ligand stimulation. |