RTI

abbr. reverse transcriptase inhibitor

RTI

Abbreviation for:
reproductive tract infection
respiratory tract infection
reverse transcriptase inhibitor
road traffic incident
routine task inventory

infection

(in-fek'shon) [L. infectio, discoloration, dye] A disease caused by microorganisms, esp. those that release toxins or invade body tissues. Worldwide, infectious diseases such as malaria, tuberculosis, hepatitis viruses, and diarrheal illnesses produce more disability and death than any other cause. Infection differs from colonization of the body by microorganisms in that during colonization, microbes reside harmlessly in the body or perform useful functions for it, e.g., bacteria in the gut that produce vitamin K. By contrast, infectious illnesses typically cause bodily harm.

Etiology

The most common pathogenic organisms are bacteria (including mycobacteria, mycoplasmas, spirochetes, chlamydiae, and rickettsiae), viruses, fungi, protozoa, and helminths. Life-threatening infectious disease usually occurs when immunity is weak or suppressed (such as during the first few months of life, in older or malnourished persons, in trauma or burn victims, in leukopenic patients, and in those with chronic illnesses such as diabetes mellitus, renal failure, cancer, asplenia, alcoholism, or heart, lung, or liver disease). Many disease-causing agents, however, may afflict vigorous persons, whether they are young or old, fit or weak. Some examples include sexually transmitted illnesses (such as herpes simplex or chlamydiosis), respiratory illnesses (influenza or varicella), and food or waterborne pathogens (cholera, schistosomiasis).

Symptoms

Systemic infections cause fevers, chills, sweats, malaise, and occasionally, headache, muscle and joint pains, or changes in mental status. Localized infections produce tissue redness, swelling, tenderness, heat, and loss of function.

Transmission

Pathogens can be transmitted to their hosts by many mechanisms, namely, inhalation, ingestion, injection or the bite of a vector, direct (skin-to-skin) contact, contact with blood or body fluids, fetomaternal contact, contact with contaminated articles (fomites), or self-inoculation.

In health care settings, infections are often transmitted to patients by the hands of professional staff or other employees. Hand hygiene before and after patient contact prevents many of these infections.

Defenses

The body's defenses against infection begin with mechanisms that block entry of the organism into the skin or the respiratory, gastrointestinal, or genitourinary tract. These defenses include chemicals, e.g., lysozymes in tears, fatty acids in skin, gastric acid, and pancreatic enzymes in the bowel; mucus that traps the organism; clusters of antibody-producing B lymphocytes, e.g., tonsils, Peyer's patches; and bacteria and fungi (normal flora) on the skin and mucosal surfaces that destroy more dangerous organisms. In patients receiving immunosuppressive drug therapy, the normal flora can become the source of opportunistic infections. Also, one organism can impair external defenses and permit another to enter; e.g., viruses can enhance bacterial invasion by damaging respiratory tract mucosa.

The body's second line of defense is the nonspecific immune response, inflammation. The third major defensive system, the specific immune response, depends on lymphocyte activation, during which B and T cells recognize specific antigenic markers on the organism. B cells produce immunoglobulins (antibodies), and T cells orchestrate a multifaceted attack by cytotoxic cells. See: B cell; T cell; inflammation for table

Spread

Once pathogens have crossed cutaneous or mucosal barriers and gained entry into internal tissues, they may spread quickly along membranes such as the meninges, pleura, or peritoneum. Some pathogens produce enzymes that damage cell membranes, enabling them to move rapidly from cell to cell. Others enter the lymphatic channels; if they can overcome white blood cell defenses in the lymph nodes, they move into the bloodstream to multiply at other sites. This is frequently seen with pyogenic organisms, which create abscesses far from the initial entry site. Viruses or rickettsiae, which reproduce only inside cells, travel in the blood to cause systemic infections; viruses that damage a fetus during pregnancy (such as rubella and cytomegalovirus) travel via the blood.

Diagnosis

Although many infections (such as those that cause characteristic rashes) are diagnosed clinically, definitive identification of infection usually occurs in the laboratory. Carefully collected and cultured specimens of blood, urine, stool, sputum, or other body fluids are used to identify pathogens and their susceptibilities to treatment.

Treatment

Many infections, like the common cold, are self-limited and require no specific treatment. Understanding this concept is crucial because the misuse of antibiotics does not help the affected patient and may damage society by fostering antimicrobial resistance, e.g., in microorganisms such as methicillin-resistant Staphylococcus aureus. Many common infections, such as urinary tract infections or impetigo, respond well to antimicrobial drugs. Others, like abscesses, may require incision and drainage.

acute infection

An infection that appears suddenly and may be of brief or prolonged duration.

airborne infection

An infection caused by inhalation of pathogenic organisms in droplet nuclei.

apical infection

An infection located at the tip of the root of a tooth.

autochthonous infection

Infection caused by organisms normally present in the patient's body. It may occur when host defenses are compromised, or when resident flora are introduced into an abnormal site.

bacterial infection

Any disease caused by bacteria. Bacteria exist in a variety of relationships with the human body. They colonize body surfaces and provide benefits, e.g., by limiting the growth of pathogens and by producing vitamins for absorption (in a symbiotic relationship). Bacteria can coexist with the human body without producing harmful or beneficial effects (in a commensal relationship). Bacteria may also invade tissues, damage cells, trigger systemic inflammatory responses, and release toxins (in a pathogenic or infectious relationship). See: bacterium for table

bladder infection

See: urinary tract infection

blood-borne infection

An infection transmitted through contact with the blood (cells, serum, or plasma) of an infected individual. The contact may occur sexually, through injection, or via a medical or dental procedure in which a blood-contaminated instrument is inadvertently used after inadequate sterilization. Examples of blood-borne infections include hepatitis B and C and AIDS. needle-stick injury;

breakthrough infection

An infection that occurs despite previous vaccination.

chronic infection

An infection having a protracted course.

concurrent infection

The existence of two or more infections at the same time. See: superinfection

cross infection

The transfer of an infectious organism or disease from one patient in a hospital to another.

cryptogenic infection

An infection whose source is unknown.

cytomegalovirus infection

Abbreviation: CMV infection
A persistent, latent infection of white blood cells caused by cytomegalovirus (CMV). Approx. 60% of people over 35 have been infected with CMV, usually during childhood or early adulthood; the incidence appears to be higher in those of low socioeconomic status. Primary infection is usually mild in people with normal immune function, but CMV can be reactivated and cause overt disease in pregnant women, AIDS patients, or those receiving immunosuppressive therapy following organ transplantation. CMV has been isolated from saliva, urine, semen, breast milk, feces, blood, and vaginal secretions of those infected; it is usually transmitted through contact with infected secretions that retain the virus for months to years.

During pregnancy, the woman can transmit the virus transplacentally to the fetus with devastating results. Approx. 10% of infected infants develop CMV inclusion disease, marked by anemia, thrombocytopenia, purpura, hepatosplenomegaly, microcephaly, and abnormal mental or motor development; more than 50% of these infants die. Most fetal infections occur when the mother is infected with CMV for the first time during this pregnancy, but they may also occur following reinfection or reactivation of the virus. Patients with AIDS or organ transplants may develop disseminated infection that causes retinitis, esophagitis, colitis, meningoencephalitis, pneumonitis, and inflammation of the renal tubules.

Etiology

CMV is transmitted from person to person by sexual activity, during pregnancy or delivery, during organ transplantation, or by contaminated secretions; rarely, (5%) blood transfusions contain latent CMV. Health care workers caring for infected newborns or immunosuppressed patients are at no greater risk for acquiring CMV infection than are those who care for other groups of patients (approx. 3%). Pregnant women and all health care workers should strictly adhere to standard infection control precautions.

Symptoms

Primary infection in the healthy is usually asymptomatic, but some people develop mononucleosis-type symptoms (fever, sore throat, swollen glands). Symptoms in immunosuppressed patients are related to the organ system infected by CMV and include blurred vision progressing to blindness; severe diarrhea; and cough, dyspnea, and hypoxemia. Antibodies seen in the blood identify infection but do not protect against reactivation of the virus.

Treatment

Antiviral agents such as ganciclovir and foscarnet are used to treat retinitis, colitis, and pneumonitis in immunosuppressed patients; chronic antiviral therapy has been used to suppress CMV, but this protocol has not been effective in preventing recurrence of CMV or development of meningoencephalitis. Ganciclovir has limited effect in congenital CMV. No vaccine is available.

Patient care

Health care providers can help prevent CMV infections by advising pregnant women and the immunocompromised to avoid exposure to contact with people who have confirmed and or suspected cases of CMV. The virus spreads from one person to another as a result of exposure to blood (as in transfusions) and other body fluids including feces, urine, and saliva. Contact with the diapers or drool of an infected child may result in infection of a person who has previously been unexposed to the infection. CMV is the most common congenital infection, affecting about 35,000 newborns each year. CMV infection that is newly acquired during the first trimester of pregnancy can be esp. hazardous to the developing fetus. As a result, young women who have no antibodies to CMV should avoid providing child care to infected youngsters. In the U.S., nurses who have failed to advise infected patients of the risk that CMV may pose to others have been judged to be negligent by the courts. Parents of children with severe congenital CMV require support and counseling. Although CMV infection in most nonpregnant adults is not harmful, it can cause serious illnesses or death in people with HIV/AIDS, organ transplants, and those who take immunosuppressive or cancer chemotherapeutic drugs. Infected immunosuppressed patients with CMV should be advised about the uses of prescribed drug therapies, the importance of completing the full course of therapy, and adverse effects to report for help in managing them. Family caregivers for infected people should be taught to observe standard precautions when handling body secretions. Since asymptomatic people may have and secrete the virus, standard precautions should be maintained by health care professionals at all times when such secretions are present or being handled.

deep neck infection

An infection that enters the fascial planes of the neck after originating in the oral cavity, pharynx, or a regional lymph node. It may be life-threatening if the infection enters the carotid sheath, the paravertebral spaces, or the mediastinum. Death may also result from sepsis, asphyxiation, or hemorrhage. Aggressive surgical therapy is usually required because antibiotics alone infrequently control the disease.

diabetic foot infection

A polymicrobial infection of the bones and soft tissues of the lower extremities of patients with diabetes mellitus, typically those patients who have vascular insufficiency or neuropathic foot disease. Eradication of the infection may require prolonged courses of antibiotics, surgical débridement or amputation, or reconstruction or bypass of occluded arteries. Synonym: diabetic foot ulcer See: illustration

droplet infection

An infection acquired by the inhalation of a microorganism in the air, esp. one added to the air by sneezing or cough.

focal infection

Infection occurring near a focus, such as the cavity of a tooth.

fungal infection

Pathological invasion of the body by yeast or other fungi. Fungi are most likely to produce disease in patients whose immune defenses are compromised. See: table

fungal infection of nail

Infection of a nail by one of a number of fungi. Systemic therapy with antifungal drugs may eradicate the infection.

health-care associated infection

Abbreviation: HAI
Nosocomial infection.

hospital-acquired infection

Nosocomial infection.

inapparent infection

An infection that is asymptomatic or is not detected.

local infection

An infection that has not spread but remains contained near the entry site.

low-grade infection

A loosely used term for a subacute or chronic infection with only mild inflammation and without pus formation.

nosocomial infection

An infection acquired in a hospital, nursing home, or other health care setting. Patients in burn units and surgical intensive care units have the highest rates of nosocomial infections. Synonym: health-care associated infection; hospital-acquired infection

Patient care

Hospital-acquired infections result from the exposure of debilitated patients to the drug-altered environment of the hospital, where indwelling urinary catheters, intravenous lines, and endotracheal tubes enter normally sterile body sites and allow microbes to penetrate and multiply. Over 2 million nosocomial infections occur in the U.S. annually. Antibiotic-resistant organisms such as Enterobacter spp., Pseudomonas spp., staphylococci, enterococci, Clostridium difficile, and fungi often are responsible for the infectious outbreaks that result. Standard precautions and infection control procedures limit the incidence of nosocomial infections.

opportunistic infection

Abbreviation: OI
1. Any infection that results from a defective immune system that cannot defend against pathogens normally found in the environment. Common types include bacterial (Pseudomonas aeruginosa), fungal (Candida albicans), protozoan (Pneumocystis jirovecii), and viral (cytomegalovirus). Opportunistic infections are seen in patients with impaired defenses against disease, such as those with cystic fibrosis, poorly controlled diabetes mellitus, acquired or congenital immune deficiencies, or organ transplants. 2. An infection that results when resident flora proliferate and infect a body site in which they are normally present or at some other location. In healthy humans, the millions of bacteria in and on the body do not cause infection or disease. Host defenses and interaction with other microorganisms prevent excess growth of potential pathogens. A great number of factors, many poorly understood, may allow a normal bacterial resident to proliferate and cause disease.

pocket infection

Infection of the tissues beneath the skin into which an implanted device, such as a pacemaker or defibrillator, has been surgically inserted.

protozoal infection

An infection with a protozoon, e.g., malaria.

pyogenic infection

An infection resulting from pus-forming organisms.

reproductive tract infection

Abbreviation: RTI
Any infection of the reproductive organs. The most common causes are sexually transmitted diseases, but infections may also result from bacterial overgrowth or occasionally when instruments used in medical procedures introduce microorganisms. In women RTIs can cause pelvic pain, subfertility, infertility, or damage to the developing fetus. RTIs in men include epididymitis, prostatitis, and urethritis.

risk for infection

An immunocompromised state.

secondary infection

An infection made possible by a primary infection that lowers the host's resistance, e.g., bacterial pneumonia following influenza.

slow virus infection

An infection caused by a virus that remains dormant in the body for a prolonged period before causing signs and symptoms of illness. Such viruses may require years to incubate before causing diseases. Examples include progressive multifocal leukoencephalopathy and subacute sclerosing panencephalitis.

subacute infection

An infection intermediate between acute and chronic.

subclinical infection

An infection that is immunologically confirmed but does not produce obvious symptoms or signs.

surgical site infection

An infection that occurs within thirty days of an operation, either at the suture line, just beneath it, or in internal organs and spaces that were operated upon. Synonym: surgical wound infection

surgical wound infection

Surgical site infection.

systemic infection

An infection in which the infecting agent or organisms circulate throughout the body.

terminal infection

An often fatal infection appearing in the late stage of another disease.

transfusion-associated bacterial infection

Transfusion-transmitted bacterial infection.

transfusion-transmitted bacterial infection

Abbreviation: TTBI.
Illness in a transfusion recipient that develops after the infusion of contaminated blood or blood products, esp. platelets. It usually results from colonization of the blood product during handling or storage or, less frequently, from an unsuspected infection in the blood donor. Coagulase-negative staphylococci are often responsible. Other bacteria that sometimes cause TTBI include Pseudomonas species, Anaplasma, Babesia, and Rickettsia.

Viruses may also be transmitted from blood donors to transfusion recipients. They may include cytomegalovirus, encephalitis viruses, and, rarely, hepatitis viruses or human immunodeficiency virus.

Synonym: transfusion-associated bacterial infection

upper respiratory infection

Abbreviation: URI
An imprecise term for any infection involving the nasal passages, pharynx, and bronchi. The cause is usually bacterial or viral, and, occasionally, fungal.

urinary tract infection

Abbreviation: UTI
Infection of the kidneys, ureters, or bladder by microorganisms that either ascend from the urethra (95% of cases) or that spread to the kidney from the bloodstream (5%). About 7 million Americans visit health care providers each year because of UTIs. These infections commonly occur in otherwise healthy women, men with prostatic hypertrophy or bladder outlet obstruction, children with congenital anatomical abnormalities of the urinary tract, and patients with urinary stasis related to incomplete bladder emptying, neurogenic bladder or indwelling bladder catheters. See: clean-catch method; cystitis; pyelonephritis; urethritis

Etiology

Escherichia coli causes about 80% of all UTIs. In young women, Staphylococcus saprophyticus is also common. In men with prostate disease, enterococci are often responsible. The small remaining percentage of infections may be caused by Klebsiella species, Proteus mirabilis, Staphylococcus aureus, Pseudomonas aeruginosa, or other virulent organisms.

Symptoms

The presenting symptoms of UTI vary enormously. Young patients with bladder infections may have pain with urination; urinary frequency or urgency, or both; pelvic or suprapubic discomfort; low-grade fevers; or a change in the appearance or odor of their urine (cloudy, malodorous, or rarely bloody). Older patients may present with fever, lethargy, confusion, delirium, or coma caused by urosepsis. Patients with pyelonephritis often complain of flank pain, prostration, nausea, vomiting, diarrhea, and high fevers with shaking chills. UTI may also be asymptomatic, esp. during pregnancy. Asymptomatic UTI during pregnancy is a contributing factor to maternal pyelonephritis, or fetal prematurity and stillbirth.

Diagnosis

Urinalysis (obtained either as a clean catch or catheterized specimen) and subsequent urinary culture are used to determine the presence of UTI, the suspect microorganism, and the optimal antibiotic therapy. A dipstick test may identify leukocyte esterase and nitrite in a urinary specimen, strongly suggesting a UTI. The presence of more than 8 to 10 white blood cells per high-power field of spun urine also strongly suggests UTI, as does the presence of bacteria in an uncentrifuged urinary specimen.

Treatment

Sulfa drugs, nitrofurantoin, cephalosporins, or quinolones may be used for the outpatient treatment of UTIs while the results of cultures are pending. Patients sick enough to be hospitalized may also be treated with intravenous aminoglycosides, medicine to treat nausea and vomiting, and hydration. The duration of therapy and the precise antibiotics used depend on the responsible organism and the underlying condition of the patient. Patients with anatomical abnormalities of the urinary tract, e.g., children with ureteropelvic obstruction or older men with bladder outlet obstruction, may sometimes require urological surgery.

Risk Factors

The following conditions predispose sexually active women to development of UTI: the use of a contraceptive diaphragm, the method of sexual intercourse, (greatly prolonged or cunnilingus), and failure to void immediately following intercourse.

Prevention of UTI in Young Women

Fluid intake should be increased to and maintained at to six to eight glasses daily. Although cranberry and other fruit juices are often recommended for patients with UTI, there is little objective evidence to show they have an impact. The urinary tract anesthetic phenazopyridine and sitz baths may provide relief from perineal discomfort. The anal area should be wiped from front to back or wipe the front first to prevent carrying bacteria to the urethral area; the bladder should be emptied shortly before and after intercourse; the genital area should be washed before intercourse; if vaginal dryness is a problem, water-soluble vaginal lubricants should be used before intercourse; a contraceptive diaphragm, cap, shield, or sponge should not remain in the vagina longer than necessary. An alternative method of contraception should be considered.

Patient care

Instructing the patient should emphasize self-care and prevention of recurrences. The antibiotic regimen should be explained, and the patient should be aware of signs and symptoms and, when they occur, should report them promptly to the primary caregiver.

yeast infection

A colloquial term for vulvovaginal candidiasis.

Superficial Fungal Infections
Disease	Causative Organisms	Structures Infected	Microscopic Appearance
Epidermophytosis (e.g., dhobie itch)	Epidermophyton, (e.g., floccosum)	Inguinal, axillary, and interdigital folds; hairs not affected	Long, wavy, branched, and segmented hyphae and spindle-shaped cells in stratum corneum
Favus (tinea favosa)	Trichophyton schoenleinii	Epidermis around a hair; all parts of body; nails	Vertical hyphae and spores in epidermis; sinuous branching mycelium and chains in hairs
Ringworm (tinea, otomycosis)	Microsporum (e.g., audouinii)	Horny layer of epidermis and hairs, chiefly of scalp	Fine septate mycelium inside hairs and scales; spores in rows and mosaic plaques on hair surface
	Trichophyton (e.g., tonsurans)	Hairs of scalp, beard, and other parts; nails	Mycelium of chained cubical elements and threads in and on hairs; often pigmented
Thrush and other forms of candidiasis	Candida albicans	Tongue, mouth, throat, vagina, and skin	Yeastlike budding cells and oval thick-walled bodies in lesion
Systemic Fungal Infections
Aspergillosis	Aspergillus fumigatus	Lungs	Y-shaped branching of septate hyphae
Blastomycosis	Blastomyces brasiliensis, B. dermatitidis	Skin and lungs	Yeastlike cells demonstrated in lesion
Candidiasis	Candida albicans	Esophagus, lungs, peritoneum, mucous membranes	Small, thin-walled, ovoid cells
Coccidioidomycosis	Coccidioides immitis	Respiratory tract	Nonbudding spores containing many endospores, in sputum
Cryptococcosis	Cryptococcus neoformans	Meninges, lungs, bone, skin	Yeastlike fungus having gelatinous capsule; demonstrated in spinal fluid
Histoplasmosis	Histoplasma capsulatum	Lungs	Oval, budding, uninucleated cells

reproductive tract infection

inhibitor

(in-hib'it-or) An agent that blocks a cellular receptor, stops a chemical reaction, prevents an enzyme from working, or suppresses a muscle or nerve.

ACE inhibitor

Any of a class of drugs that block the effects of angiotensin-converting enzyme, preventing the formation of angiotensin II and therefore preventing a rise in blood pressure. Drugs from this class are used to treat hypertension, heart failure, myocardial infarction, and, in diabetics, to prevent and treat chronic kidney disease.

acetylcholinesterase inhibitor

Cholinesterase inhibitor.

alpha–2 plasmin inhibitor

Alpha–2 antiplasmin.

alpha-glucosidase inhibitor

An oral drug that lowers blood sugars by preventing carbohydrate absorption from the gastrointestinal tract.

5-alpha reductase inhibitor

A medication to treat benign prostatic hyperplasia. It blocks the conversion of testosterone to dihydrotestosterone.

angiotensin-converting enzyme inhibitor

Abbreviation: ACE inhibitor.
Any of the therapeutic agents that inhibit conversion of angiotensin I to angiotensin II. ACE inhibitors are used to treat hypertension and heart failure and to protect kidney function in patients with diabetes mellitus.

aromatase inhibitor

Any of a class of drugs that block the synthesis of estrogen in the body. A number of these agents have been developed to treat breast cancer, which is often a hormone-responsive malignancy.

attachment inhibitor

Entry inhibitor.

bone resorption inhibitor

A class of drugs that prevent or retard osteoporosis. Examples include the bisphosphonates.

cholesteryl ester transfer protein inhibitor

Any drug that inhibits the transfer of cholesteryl esters from high-density lipoproteins (HDLs) to other lipoproteins. Drugs from this class increase HDL levels, potentially improving the lipid profiles of patients and decreasing their risk of atherosclerosis.

cholinesterase inhibitor

Abbreviation: ChEI
Any of a class of drugs that prevent the degradation of the neurotransmitter acetylcholine, which is involved in memory and learning. Drugs from this class are used to treat Alzheimer’s dementia. Synonym: acetylcholinesterase inhibitor

competitive inhibitor

1. A chemical that binds to or blocks another reagent from participating in a reaction. 2. A medication, hormone, or other intercellular messenger that binds and blocks the cellular receptor or target enzyme of another agent. Drugs that act by competitive inhibition may treat or prevent disease by inactivating pathogenic enzymes or by blocking the effects of hormones or precursor molecules. For example, protease inhibitors interfere with production of human immunodeficiency virus (HIV) by binding and inactivating the protease enzyme; selective estrogen-receptor modulators limit the impact of estrogen by replacing this hormone on cells sensitive to its effects.

cyclooxygenase inhibitor

Any agent that suppresses inflammation by blocking the inflammatory effects of cyclooxygenase.

dipeptidyl peptidase-4 inhibitor

Abbreviation: DPP-4 inhibitor
Gliptin.

direct thrombin inhibitor

Abbreviation: DP
Any medication or substance that interferes with the coagulation of blood by blocking the action of thrombin. Unlike heparins, which are anticoagulants that require the presence of antithrombin to inactivate thrombin, DTIs exert their effects without an intermediary. DTIs can be used to treat and prevent clots in both arteries and veins (although heparin and warfarin are usually preferred for these uses). They are an alternative to heparin in patients with a history of heparin-induced thrombocytopenia. The primary side effect of DTIs is bleeding.

DPP-4 inhibitor

dipeptidyl peptidase-4 inhibitor.

dual reuptake inhibitor

An antidepressant medication that works by blocking the reuptake of both serotonin and norepinephrine.

entry inhibitor

Any agent that prevents a pathogen (e.g., human immunodeficiency virus) from binding to cell membranes and infecting cells. Synonym: attachment inhibitor

glycoprotein IIB/IIIa receptor inhibitor

Any of a class of drugs that block the fibrinogen receptor on the surface of platelets. Drugs from this class are used to treat acute myocardial infarction, unstable angina pectoris, and other acute coronary syndromes. The most common side effect of treatment with these drugs is bleeding.

HMG CoA enzyme inhibitor

Statin.

integrase inhibitor

Any agent that prevents the human immunodeficiency virus from inserting its viral DNA into host cell chromosomes.

matrix metalloproteinase inhibitor

An agent that inhibits cancer cells by blocking their abilities to invade tissues, demand new blood supply, and metastasize.

metalloprotease inhibitor

Metalloproteinase inhibitor.

metalloproteinase inhibitor

Any of numerous compounds that inhibit the activity of the metalloproteinase family of enzymes. These agents share the ability to suppress or eliminate the enzyme activity of the metalloproteinases. Agents identified in this group include the tetracycline antibiotics, numerous specially designed synthetic peptides and proteins, chemicals such as ethylenediaminetetra-acetic acid (EDTA), and a variety of agents used in cancer chemotherapy. Synonym: metalloprotease inhibitor

monoamine oxidase inhibitor

Abbreviation: MAOI
Any of a group of drugs that can be used to treat depression and Parkinson's disease. Nonselective versions of these medications produced hypertensive crises and other severe side effects when they were taken with tyramine-containing foods (some cheeses) and several other drugs. Newer members of this class of drugs do not have these effects, but should be used with caution, esp. by those taking selective serotonin reuptake inhibitors.

CAUTION!

MAOIs may have unfavorable drug-drug interactions with many anesthetics and should be discontinued approximately two weeks before surgery. See: tyramine

neuraminidase inhibitor

Any of a class of antiviral drugs that block neuraminidase, which helps the influenza virus to bud from cells it has infected so that it can spread to other ciliated epithelial cells of the respiratory tract. Agents in this class include oseltamivir and zanamivir.

nonnucleoside analog reverse transcriptase inhibitor

Abbreviation: NNRTI
Any of a class of antiretroviral drugs used to treat those infected with HIV. NNRTIs bind with and inhibit the activity of reverse transcriptase, an enzyme needed to transcribe viral RNA into the host cell DNA. Examples include nevirapine, delavirdine, and efavirenz.

nucleoside reverse transcriptase inhibitor

Abbreviation: NRTI
Any of a class of antiretroviral drugs used to treat patients with HIV infection. NRTIs prevent transcription of viral RNA to host DNA by interfering with the action of the enzyme reverse transcriptase. Zidovudine, dideoxyinosine, zalcitabine, d4T, and abacavir are NRTIs. See: reverse transcriptase inhibitor

phosphodiesterase inhibitor

Abbreviation: PDE inhibitor
Any agent that blocks phosphodiesterase, inhibiting the production of second messengers within cells, such as cyclic adenosine monophosphate or cyclic glucose monophosphate. Drugs that inhibit PDE include sildenafil, an agent used to treat erectile dysfunction, and other agents used as positive inotropes and vasodilators in heart failure.

prostaglandin inhibitor

A substance that inhibits the production of prostaglandins. Nonsteroidal and steroidal anti-inflammatory agents are two major categories of such inhibitors.

protease inhibitor

1. A substance that inhibits the action of enzymes.2. Any of a class of medications that prevent immature virions (as of hepatitis viruses or HIV) from assembling into structures capable of replication.

proton pump inhibitor

Abbreviation: PPI
Any of a class of medications that eliminate acid production in the stomach. Thes drugs are used to treat peptic ulcers, gastroesophageal reflux disease, Heliobacter pylori infection, and related disorders. Omeprazole and lansoprazole are members of this drug class.

reverse transcriptase inhibitor

Abbreviation: RTI
Any of a class of antiretroviral agents that competitively inhibit the reverse transcriptase enzyme of HIV and other viruses. See: antiretroviral

selective serotonin reuptake inhibitor

Abbreviation: SSRI
Any of a class of drugs that interfere with serotonin transport, used in treating depression, obsessive-compulsive behaviors, eating disorders, and social phobias. Examples include fluoxetine (Prozac), paroxetine (Paxil), and sertraline.

CAUTION!

The use of SSRIs in the treatment of depression may sometimes be associated with an increased risk of suicide, esp. during the initiation of treatment. The risk is greatest among children and adolescents. All patients who begin treatment with SSRIs should be monitored closely for evidence that they intend to harm themselves.

serine protease inhibitor

Abbreviation: serpin
Any of the compounds that inhibit platelet function and coagulation. Serpins have been used to reduce deposition of microemboli in cases of disseminated intravascular coagulation associated with sepsis.

serotonin and norepinephrine reuptake inhibitor

Abbreviation: SNRI
An antidepressant medication (such as duloxetine or venlafaxine) that elevates mood by blocking neurons from taking up both norepinephrine and serotonin. Combined reuptake inhibitors differ from medications such as sertraline (Zoloft) or fluoxetine (Prozac), which are relatively selective serotonin reuptake inhibitors, and from tricyclic antidepressants, which primarily prevent the reuptake of norepinephrine by brain cells. SNRIs treat neuropathic pain as well as depression.

tumor necrosis factor alpha inhibitor

A drug that blocks the effects of tumor necrosis factor alpha (TNF-alpha), a biologically active cytokine that is a critical element of the inflammatory response. Such drugs, which include adalimumab, etanercept, and infliximab, are agents used to treat autoimmune illnesses such as rheumatoid arthritis.

CAUTION!

Because these drugs are immunologically active, patients with active infection or those with chronic infections such as tuberculosis should not use them. These agents also sometimes increase the risk of cancers and have rarely been associated with demyelinating diseases of the central nervous system such as multiple sclerosis.

vasopeptidase inhibitor

Any of a class of medications that blocks the actions of both angiotensin converting enzymes (ACE) and neural endopeptidase. Drugs from this class may be used to treat heart failure.

reverse transcriptase inhibitor

Abbreviation: RTI
Any of a class of antiretroviral agents that competitively inhibit the reverse transcriptase enzyme of HIV and other viruses. See: antiretroviralSee also: inhibitor