释义 |
trinucleotide repeat expansion
trinucleotide repeat expansion[‚trī¦nü·klē·ə‚tīd ri′pēt ik‚span·shən] (genetics) An increase in the number of copies of a trinucleotide that is normally already present in multiple adjacent copies. For example, the X-linked mental retardation 1 (XLMRI) locus in humans usually contains 6-50 tandem repeats of CCG, but this is expanded to 200-2000 copies in the fragile-X syndrome. Trinucleotide repeat expansion
Trinucleotide repeat expansionA sequence of three nucleotides that is repeated too many times in a section of a gene.Mentioned in: Myotonic Dystrophy |