preleukemia

[pre″loo-ke´me-ah] a stage of bone marrow dysfunction preceding the development of acute myelogenous leukemia. adj., adj preleuke´mic.

myelodysplastic syndrome

a heterogeneous group of clonal hematopoietic stem cell disorders characterized by the presence of dysplastic changes in one or more of hematopoietic lineages. The common clinical picture may include anemia, infections, and bleeding problems. Occurs generally in elderly patients, or those with prior exposure to leukemogenic agents. Transformation rates to acute leukemia range from 10-80%. Cytogenetic abnormalities are associated with a poor prognosis. Synonym(s): preleukemia, smoldering leukemia

preleukemia

Myelodysplastic syndrome, smoldering leukemia Any of a heterogeneous group of clonal expansions of stem cells, characterized by dysmyelopoiesis–a complex of structural and functional defects–eg, abnormal cell morphology, ineffective hematopoiesis, chromosome defects–eg, aneuploidy and pseudodiploidy Examples Acquired idiopathic sideroblastic and nonsideroblastic anemias, pancytopenia with hypercellular marrow, paroxysmal nocturnal hemoglobinuria, which may all progress to ANLL

my·e·lo·dys·plas·tic syn·drome

(mī'ĕ-lō-dis-plast'ik sin'drōm) A primary, neoplastic, pluripotential stem cell disorder characterized by peripheral blood cytopenias and prominent maturation abnormalities in the bone marrow. The disease evolves progressively and may transform into leukemia. Classified by the French-American-British (FAB) system (q.v.) into five groups.
Synonym(s): chronic erythremic myelosis, preleukemia, smoldering leukemia.

单词	preleukemia
释义	DictionarySeemyelodysplastic syndrome preleukemia preleukemia [pre″loo-ke´me-ah] a stage of bone marrow dysfunction preceding the development of acute myelogenous leukemia. adj., adj preleuke´mic. myelodysplastic syndrome a heterogeneous group of clonal hematopoietic stem cell disorders characterized by the presence of dysplastic changes in one or more of hematopoietic lineages. The common clinical picture may include anemia, infections, and bleeding problems. Occurs generally in elderly patients, or those with prior exposure to leukemogenic agents. Transformation rates to acute leukemia range from 10-80%. Cytogenetic abnormalities are associated with a poor prognosis. Synonym(s): preleukemia, smoldering leukemia preleukemia Myelodysplastic syndrome, smoldering leukemia Any of a heterogeneous group of clonal expansions of stem cells, characterized by dysmyelopoiesis–a complex of structural and functional defects–eg, abnormal cell morphology, ineffective hematopoiesis, chromosome defects–eg, aneuploidy and pseudodiploidy Examples Acquired idiopathic sideroblastic and nonsideroblastic anemias, pancytopenia with hypercellular marrow, paroxysmal nocturnal hemoglobinuria, which may all progress to ANLL my·e·lo·dys·plas·tic syn·drome (mī'ĕ-lō-dis-plast'ik sin'drōm) A primary, neoplastic, pluripotential stem cell disorder characterized by peripheral blood cytopenias and prominent maturation abnormalities in the bone marrow. The disease evolves progressively and may transform into leukemia. Classified by the French-American-British (FAB) system (q.v.) into five groups. Synonym(s): chronic erythremic myelosis, preleukemia, smoldering leukemia.
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