senile plaque


se·nile plaque

an obsolete term for neuritic plaque.

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak) A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.

Senile plaque

—Structures composed of parts of neurons surrounding brain proteins called beta-amyloid deposits found in the brains of people with AD.Mentioned in: Alzheimer's Disease