tetrodotoxin

te·tro·do·tox·in

T0133850 (tĕ-trō′də-tŏk′sĭn)n. A potent neurotoxin, C₁₁H₁₇N₃O₈, found in many pufferfishes and certain other animals, including some salamanders and crabs.

[Shortening and alteration of New Latin Tetraodōn, pufferfish genus (Greek tetra-, tetra- + New Latin -odōn, -odon (so called because members of the genus have two upper and two lower teeth)) + toxin.]

tetrodotoxin

(ˌtɛtrəʊdəʊˈtɒksɪn) n (Zoology) a highly lethal neurotoxin found in certain puffer fish and in newts of the genus Taricha. Formula: C11H17N3O3[C20: from New Latin Tetrodon (puffer fish genus name, from Greek tetra- fourfold + odont- tooth) + toxin]

te•tro•do•tox•in

(tɛˌtroʊ dəˈtɒk sɪn)

n. a neurotoxin, C₁₁H₁₇N₃O₃, occurring in a species of puffer fish: ingestion may be fatal. [1910–15; < New Latin Tetrodo(n) genus name of the puffer fish + toxin]

Thesaurus

Noun

tetrodotoxin - a powerful neurotoxin found in the ovaries of pufferfishblowfish, puffer, pufferfish, sea squab - delicacy that is highly dangerous because of a potent nerve poison in ovaries and liverneurolysin, neurotoxin - any toxin that affects neural tissues

tetrodotoxin

[tet´ro-do-tok″sin] a highly lethal neurotoxin" >neurotoxin present in numerous species of puffer fish" >puffer fish and in newts of the genus Taricha (in the latter it is called tarichatoxin); ingestion results in tetrodotoxism" >tetrodotoxism.

tet·ro·do·tox·in (TTX),

(tet'rō-dō-tok'sin), A potent neurotoxin found in the liver and ovaries of the Japanese pufferfish, Sphoeroides rubripes, other species of pufferfish, and some newts; produces axonal blocks of the preganglionic cholinergic fibers and the somatic motor nerves. Tetrodotoxin blocks voltage-gated Na⁺ channels in excitable tissues.

tetrodotoxin

(tĕ-trō′də-tŏk′sĭn)n. A potent neurotoxin, C₁₁H₁₇N₃O₈, found in many pufferfishes and certain other animals, including some salamanders and crabs.

tetrodotoxin

A potent, heat-stable neurotoxin concentrated in certain tissues—liver, gonads, intestines and skin of fishes of order Tetraodontoidea (ocean sunfish, porcupine fish, and pufferfish/fugu); it is also present in lethal amounts in the California newt and eastern salamander.

Mechanism of action
Tetrodotoxin blocks conduction of sodium across membranes and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it.

Clinical findings
Paraesthaesias begin 10-45 minute after ingestion, commonly as intraoral and tongue tingling; often associated with nausea, vomiting, light-headedness, vertigo, a sense of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, fixed dilated pupils.

Management
IV hydration, gastric lavage, activated charcoal.

tetrodotoxin

Toxicology A potent heat-stable neurotoxin concentrated in fishes of order Tetraodontoidea; tetrodotoxin blocks conduction of sodium across membranes, and neural transmission in skeletal muscle, and kills up to 60% of those who ingest it, causing 50 deaths/yr in Japan Clinical Paresthesias begin 10-45 mins after ingestion, commonly as intraoral and tongue tingling, often associated with N&V, lightheadedness, vertigo, feelings of doom, weakness, hypersalivation, muscle twitching, diaphoresis, pleuritic chest pain, dysphagia, aphonia, convulsions, hypotension, bradycardia, depressed corneal reflexes, and fixed dilated pupils Management IV hydration, gastric lavage, activated charcoal

tetrodotoxin

Puffer fish toxin, one of the most powerful known neurotoxins with a mortality of about 50%. There is no known antidote.

tetrodotoxin

te·tro·do·tox·in

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tet·ro·do·tox·in (TTX),

tetrodotoxin

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Words related to tetrodotoxin

noun a powerful neurotoxin found in the ovaries of pufferfish

Related Words