Apresoline
Noun | 1. | Apresoline - an antihypertensive drug (trade name Apresoline) that dilates blood vessels; used (often with a diuretic) to treat hypertension and congestive heart failure |
单词 | apresoline | |||
释义 | Apresoline
Apresolinehydralazine hydrochloridePharmacologic class: Peripheral vasodilator Therapeutic class: Antihypertensive Pregnancy risk category C ActionRelaxes vascular smooth muscles of arteries and arterioles, causing peripheral vasodilation and decreasing peripheral vascular resistance. These actions decrease blood pressure and increase heart rate, stroke volume, and cardiac output. AvailabilityInjection: 20 mg/ml Tablets: 10 mg, 25 mg, 50 mg, 100 mg Indications and dosages➣ Hypertension Adults: Initially, 10 mg P.O. q.i.d. After 2 to 4 days, may increase to 25 mg P.O. q.i.d. for remainder of first week; may then increase further to 50 mg P.O. q.i.d., up to 300 mg/day. Once maintenance dosage is established, may give in two daily doses. Children: Initially, 0.75 mg/kg/day P.O. in four divided doses; may increase gradually over 3 to 4 weeks to 7.5 mg/kg or 200 mg/day Neonates: 0.5 mg/kg P.O., I.M., or I.V. q 4 to 6 hours Contraindications• Hypersensitivity to drug or tartrazine • Coronary artery disease • Mitral valvular rheumatic heart disease PrecautionsUse cautiously in: • suspected CV or cerebrovascular disease, severe renal or hepatic disease • pregnant or breastfeeding patients • children. Administration• Administer oral form with food. See Inject I.V. form slowly over 1 minute. Monitor blood pressure response continuously. • Draw up and use parenteral drug immediately; solution changes color after contact with metal needle. Adverse reactionsCNS: dizziness, drowsiness, headache, peripheral neuritis CV: tachycardia, angina, orthostatic hypotension, arrhythmias EENT: lacrimation, nasal congestion GI: nausea, vomiting, diarrhea, constipation, anorexia Metabolic: sodium retention Musculoskeletal: joint pain, arthritis Skin: rash, blisters, flushing, pruritus, urticaria Other: chills, fever, lymphadenopathy, edema, lupuslike syndrome InteractionsDrug-drug. Antihypertensives, nitrates: additive hypotension Epinephrine: reduced pressor response to epinephrine Metoprolol, propranolol: increased blood levels of both drugs MAO inhibitors: increased hypotension Drug-diagnostic tests. Coombs' test: positive result Granulocytes, hemoglobin, neutrophils, platelets, red blood cells, white blood cells: decreased levels Drug-behaviors. Alcohol use: additive hypotensive response Patient monitoring• Monitor CBC, lupus erythematosus cell studies, and antinuclear antibody titers before and periodically during therapy. • Monitor blood pressure, pulse rate and regularity, and daily weight. • To avoid rapid blood pressure drop, taper dosage gradually before discontinuing. See Assess for lupuslike signs and symptoms, including joint pain, fever, myalgia, pharyngitis, and splenomegaly. • Watch for peripheral neuritis. If it occurs, expect to give pyridoxine. Patient teaching• Tell patient to take tablets with food. • Instruct patient to move slowly when rising (especially in morning on awakening), to avoid dizziness from sudden blood pressure decrease. See Instruct patient to immediately report fever, muscle and joint aches, or sore throat. • Tell patient to report chest pain or numbness or tingling of hands or feet. • To minimize GI upset, advise patient to eat small, frequent meals. • Caution patient not to discontinue drug abruptly, because severe hypertension may result. • As appropriate, review other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above. Apresoline®Hydralazine, see there.ApresolineA brand name for HYDRALAZINE.Apresoline
Synonyms for Apresoline
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