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substantia nigra
substantia ni·gra S0852750 (nī′grə, nĭg′rə)n. A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.
[New Latin : Latin substantia, substance + Latin nigra, feminine of niger, black.]substantia nigra (səbˈstænʃə ˈnaɪɡrə) n (Anatomy) a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease[C20: from Latin, literally: dark material]sub•stan•ti•a ni•gra (səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə)
n., pl. sub•stan•ti•ae ni•grae (sʌbˈstæn ʃiˌi ˈnaɪ gri, ˈnɪg ri) substantia ni•gras. a deeply pigmented area of the midbrain containing dopamine-producing nerve cells. [1880–85; < New Latin: black substance] Thesaurus| Noun | 1. | substantia nigra - a layer of deeply pigmented grey matter in the midbrain; associated with the striate body; is involved in metabolic disturbances associated with Parkinson's disease and with Huntington's diseaselocus niger, nucleus nigerneural structure - a structure that is part of the nervous systemmesencephalon, midbrain - the middle portion of the brain |
substantia nigra
substantia [sub-stan´she-ah] (L.) substance; used in anatomic nomenclature in naming various components of body tissues or structures.substantia al´ba white matter.substantia gelatino´sa the substance sheathing the posterior horn of the spinal cord and lining its central canal.substantia gri´sea gray matter.substantia ni´gra a dark layer of gray matter separating the tegmentum of the midbrain from the crus cerebri.sub·stan·ti·a ni'g·ra [TA] a large cell mass, crescentic on transverse section, extending forward over the inner surface of the crus cerebri from the rostral border of the pons into the subthalamic region. It is composed of a dorsal stratum of closely spaced pigmented (that is, melanin-containing) cells, the pars compacta [TA]; a larger ventral region of widely scattered cells, the pars reticulata [TA]; and smaller less distinct regions, the pars lateralis [TA] and pars retrorubralis [TA]; the pars compacta in particular includes numerous cells that project forward to the striatum (caudate nucleus and putamen) and contain dopamine, which acts as the transmitter at their synaptic endings. Other, apparently nondopaminergic, cells of the substantia nigra project to a rostral part of the ventral nucleus of thalamus, to the middle layers of the superior colliculus, and to restricted parts of the reticular formation of the midbrain. The nigrostriatal projection is reciprocated by a massive striatonigral fiber system with multiple neurotransmitters, chief among which is γ-aminobutyric acid (GABA). The substantia nigra receives smaller afferent projections from the subthalamic nucleus, the lateral segment of the globus pallidus, the dorsal nucleus of the raphe, and the pedunculopontine nucleus of the midbrain. The pars reticulata forms part of the output system for the striate body. The substantia n. is involved in the metabolic disturbances associated with Parkinson disease and Huntington disease. Synonym(s): locus niger, nucleus niger, Soemmerring ganglionsubstantia nigra (nī′grə, nĭg′rə)n. A layer of large pigmented nerve cells in the midbrain that produce dopamine and whose destruction is associated with Parkinson's disease.sub·stan·ti·a nigra (sŭb-stan'shē-ă nī'gră) [TA] A large cell mass, crescentic on transverse section, extending forward over the dorsal surface of the crus cerebri from the rostral border of the pons into the subthalamic region; it is composed of a dorsal stratum of closely spaced pigmented (i.e., melanin-containing) cells, the pars compacta, and a larger ventral region of widely scattered cells, the pars reticulata. The substantia nigra is involved in the metabolic disturbances associated with parkinsonism and Huntington disease. substantia nigra A layer of grey matter (nerve cell bodies) containing pigmented nerve cells, that spreads throughout the white substance of the midbrain and receives fibres from the BASAL GANGLIA. DOPAMINE is produced in the substantia nigra, and loss of the pigment cells is a constant finding in PARKINSON'S DISEASE.Substantia nigraOne of the movement control centers of the brain.Mentioned in: Parkinson DiseaseSoemmerring, Samuel Thomas von, German anatomist, 1755-1830. ring of Soemmerring - a mass of lenticular fibers enclosed between the anterior and posterior portion of the lenticular capsule, leaving the pupillary area relatively free.Soemmerring ganglion - a large cell mass extending forward over the dorsal surface of the crus cerebri from the rostral border of the pons into the subthalamic region. Synonym(s): substantia nigraSoemmerring ligament - small fibers attaching the lacrimal gland to the periorbita.Soemmerring muscle - a fasciculus occasionally passing from the thyrohyoid muscle to the isthmus of the thyroid gland. Synonym(s): levator muscle of thyroid glandSoemmerring spot - an oval area of the sensory retina at the center of which is the central fovea, which contains only retinal cones. Synonym(s): macula retinaeAcronymsSeeSNsubstantia nigra
Related to substantia nigra: dopamine, Cranial nerves, basal ganglia, striatumSynonyms for substantia nigranoun a layer of deeply pigmented grey matter in the midbrainSynonymsRelated Words- neural structure
- mesencephalon
- midbrain
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