| 释义 |
paraneoplastic syndromes paraneoplastic syndrome Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone. Paraneoplastic syndromes GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans Hormonal effects Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation Renal, eg nephrotic syndrome, uric acid nephropathy Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis Others, eg callus formation, hypertension, and amyloidosis paraneoplastic syndromes (pă-ră-nēō-plăs′-tĭk) Indirect effects of cancers, such as metabolic disturbances or hormonal excesses produced by chemicals released by tumor cells. Tumors such as small-cell carcinoma of the lung, hypernephroma, and neuroendocrine cancers are often responsible. paraneoplastic syndromes Syndromes caused by the secretion into the blood of the products of cancers, usually polypeptide hormones, which affect parts remote from the tumours. Thus, lung cancers can secrete ANTIDIURETIC HORMONE or ACTH and cause confusing effects. |