paraneoplastic syndrome


paraneoplastic syndrome

 [par″ah-ne″o-plas´tik] a collective term for disorders arising from metabolic effects of cancer on tissues remote from the tumor; such disorders may, for example, appear as primary endocrine, hematologic, or neuromuscular disorders.

par·a·ne·o·plas·tic syn·drome

a syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone. Paraneoplastic syndromes GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans Hormonal effects Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation Renal, eg nephrotic syndrome, uric acid nephropathy Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis Others, eg callus formation, hypertension, and amyloidosis

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm) A syndrome directly resulting from a malignant neoplasm, but not resulting from the presence of tumor cells in the affected parts.

Paraneoplastic syndrome

A set of symptoms that is associated with cancer but is not directly caused by the cancer.Mentioned in: Thymoma

par·a·ne·o·plas·tic syn·drome

(par'ă-nē-ō-plas'tik sin'drōm) Syndrome directly resulting from a malignant neoplasm, but not resulting from presence of tumor cells.