atrial septal defect type 4

atrial septal defect type 4

A rarely reported congenital heart malformation (OMIM:611363) that is clinically identical to other ASDs, which are characterised by a communication of blood flow between the left and right atria. ASD4 is caused by a defect of TBX20, which encodes a transciption factor essential for heart development, and is often accompanied by other cardiac malformations including defects in septation, chamber growth and valvulogenesis.