THRB
THRB
A gene on chromosome 3p24.2 that encodes thyroid hormone receptor, beta, a nuclear hormone receptor for triiodothyronine, and one of several thyroid hormone receptors that mediate thyroid hormone’s biological activity.Molecular pathology
THRB mutations cause generalised thyroid hormone resistance (GTHR), a condition characterised by goitre and high circulating thyroid hormone (T3–T4) levels and normal or slightly
elevated thyroid stimulating hormone (TSH).