Trental

pentoxifylline

Apo-Pentoxiphylline, Neotren (UK), Pentoxil, Pentoxiphylline (CA), Pentoxiphylline SR (CA), Trental

Pharmacologic class: Hemorrheologic, xanthine derivative

Therapeutic class: Hematologic agent

Pregnancy risk category C

Action

Unknown. Thought to enhance blood flow to the circulatory system by increasing vasoconstriction and oxygen concentrations.

Availability

Tablets (controlled-release, extended-release): 400 mg

Indications and dosages

➣ Intermittent claudication

Adults: 400 mg t.i.d. If adverse reactions occur, decrease to 400 mg b.i.d.

Dosage adjustment

• Renal impairment

Off-label uses

• Diabetic angiopathies and neuropathies

• Transient ischemic attacks

• Severe idiopathic recurrent aphthous stomatitis

• Raynaud's phenomenon

Contraindications

• Hypersensitivity to drug or methylxanthines (such as caffeine, theophylline, theobromine)

• Recent cerebral or retinal hemorrhage

Precautions

Use cautiously in:

• patients at risk for bleeding

• pregnant or breastfeeding patients

• children (safety not established).

Administration

• Give with meals to minimize GI distress.

• Make sure patient swallows tablets whole without crushing, breaking, or chewing.

Adverse reactions

CNS: agitation, dizziness, drowsiness, headache, insomnia, nervousness, tremor, anxiety, confusion, malaise

CV: angina, edema, hypotension, arrhythmias

EENT: blurred vision, epistaxis, laryngitis, nasal congestion, sore throat

GI: nausea, vomiting, constipation, diarrhea, abdominal discomfort, belching, bloating, dyspepsia, flatus, cholecystitis, dry mouth, excessive salivation, anorexia

Hematologic: leukopenia

Respiratory: dyspnea

Skin: rash, urticaria, pruritus, brittle fingernails, flushing, angioedema

Other: bad taste, weight changes, thirst, flulike symptoms, lymphadenopathy

Interactions

Drug-drug. Anticoagulants, nonsteroidal anti-inflammatory drugs (NSAIDs): increased risk of bleeding Antihypertensives: additive hypotension

Theobromide, theophylline: increased risk of theophylline toxicity

Drug-herbs. Anise, arnica, asafetida, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, licorice: increased risk of bleeding

Drug-behaviors. Smoking: decreased pentoxifylline efficacy

Patient monitoring

• Monitor vital signs and cardiovascular status. Watch for arrhythmias, angina, edema, and hypotension.

• Frequently monitor prothrombin time and International Normalized Ratio in patients receiving warfarin concurrently.

• Assess theophylline level in patients receiving theophylline-containing drugs concurrently.

Patient teaching

• Instruct patient to take with meals and to swallow tablets whole without crushing, breaking, or chewing.

See Inform patient that drug can cause serious adverse effects. Instruct him to immediately report chest pain, swelling, and flulike symptoms.

• Tell patient smoking may make drug less effective and that many over-the-counter preparations (including aspirin, NSAIDs, and herbs) increase risk of bleeding.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Trental

(trĕn′tăl′) A trademark for the drug pentoxifylline.

Trental

Pentoxifylline, see there.

Trental

A brand name for OXPENTIFYLLINE (pentoxifylline).

Trental

trental

Trental

pentoxifylline

Action

Availability

Indications and dosages

Dosage adjustment

Off-label uses

Contraindications

Precautions

Administration

Adverse reactions

Interactions

Patient monitoring

Patient teaching

Trental

Trental

Trental

Trental

Synonyms for Trental

noun a drug (trade name Trental) used to treat claudication

Synonyms

Related Words