| 单词 | topotecan |
| 释义 | topotecantopotecanA water-soluble derivative of camptothecin, obtained from the Chinese tree Camptotheca accuminata. It is a topoisomerase inhibitor which is FDA-approved for treating ovarian, cervical and small cell carcinoma of the lung.topotecanHycamtin® Oncology A topoisomerase I inhibitor used for refractory ovarian CA, small cell CA, and for colorectal and breast CAs Adverse effects Dose-limiting–never if baseline neutrophils are < 1500 cells/mm3–neutropenia, anemia, thrombocytopenia; N&V, diarrhea, alopecia Contraindications Pregnancy, breastfeeding, prior BM depression. See Topoisomerase I.topotecanThe first of the CAMPOTHECIN analogue drugs to be approved for clinical use. Topotecan is a TOPOISOMERASE inhibitor drug used to treat cancer of the ovary and small cell cancer of the lung. (see CYTOTOXIC DRUGS). A brand name is Hycamtin. |
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