Paget's disease

Pag·et's disease

P0012250 (păj′ĭts) or Pag·et disease (-ĭt)n.1. A disease, occurring chiefly in old age, in which the bones become enlarged and weakened, often resulting in fracture or deformation. Also called Paget's disease of bone.2. A rare form of breast cancer involving the areola and nipple and usually associated with underlying ductal carcinoma. Also called Paget's disease of the breast, Paget's disease of the nipple.

[After Sir James Paget.]

Paget's disease

(ˈpædʒɪts) n1. (Pathology) Also called: osteitis deformans a chronic disease of the bones characterized by inflammation and deformation2. (Pathology) Also called: Paget's cancer cancer of the nipple and surrounding tissue[C19: named after Sir James Paget (1814–99), British surgeon and pathologist, who described these diseases]

Pag′et's disease`

(ˈpædʒ ɪts)

n. 1. a disease characterized by episodic accelerated bone resorption and growth of abnormal replacement bone. 2. an inflammatory condition of the nipple associated with breast cancer. [1875–80; after James Paget (1814–99), English surgeon]

Paget's disease

A disease that involves the abnormal formation and resorption of bone. Bones become soft, weak, thickened, and deformed.

Thesaurus

Noun

Paget's disease - a disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain and fractures and skeletal deformitiesosteitis deformansosteitis - inflammation of a bone as a consequence of infection or trauma or degeneration

Paget's disease

[paj´ets] any of three diseases named after Sir James Paget (1814–1889): Paget's disease of bone, Paget's disease of the breast, and extramammary Paget's disease.
Paget's disease of bone is a localized bone disorder that is also called osteitis deformans. It is relatively common, particularly in the United States, United Kingdom, Australia, France, and Germany, occurring in 3 per cent of the population over the age of 40 and 10 per cent of those over the age of 70. It occurs more often in males than in females. Once thought to be a rare form of localized bone disease, the disorder is now diagnosed more frequently because of newer diagnostic techniques, such as bone scanning, and routine testing of plasma alkaline phosphatase.
Symptoms of Paget's disease of bone depend on the site of the bone lesions and their severity. In 20 per cent of diagnosed cases there are no symptoms at all, and in others the symptoms are very mild. Lesions in the long bones seem to cause the most difficulty. The disease disturbs the growth of new bone tissue with the result that the bones often thicken, become soft, and coarsen in texture. In an advanced case, the weakened bone may be fractured by even a light blow, or, as in the case of the vertebrae, may collapse.
Lesions in the long bones can cause pain, deformity from bowing, and disability due to the arthritic changes that are a complication of the disease. When the disease process affects the skull the patient may complain of headaches, intermittent ringing in the ears and dizziness, and hearing loss. Severe involvement of the occipital region can cause pressure on the pons and cerebellum and compression of the spinal cord. These pathologic changes produce loss of coordination, muscle weakness, diplopia, ataxia, and other signs of neurologic dysfunction.
Diagnosis of this disease is verified by radiologic studies of the affected bones and by laboratory tests. The serum alkaline phosphatase and urinary hydroxyproline levels are elevated. Drugs of choice for its treatment are calcitonin, mithramycin, and etidronate disodium.
Paget's disease of the breast is an erythematous scaling lesion of the breast, involving the nipple and areola unilaterally, and associated with an underlying malignancy. It usually appears around the age of 55 in women, but can also affect males. (See Atlas 2, Part I.)
Extramammary Paget's disease is characterized by similar lesions occurring in middle-aged women and men, but the lesions are located in the anogenital area. The skin disorder is not always associated with malignancy, as it is when affecting the breast, but in almost half the cases there is an underlying carcinoma.

Paget's disease

(păj′ĭts) or

Paget disease

(-ĭt)n.1. A disease, occurring chiefly in old age, in which the bones become enlarged and weakened, often resulting in fracture or deformation. Also called Paget's disease of bone.2. A rare form of breast cancer involving the areola and nipple and usually associated with underlying ductal carcinoma. Also called Paget's disease of the breast, Paget's disease of the nipple.

Paget's disease

A bone disease affecting up to 3% of the elderly population and involving mainly the skull, the collar bones (clavicles) the spine, the pelvis and the leg bones. The affected areas become warm with softening and increased bone growth with distortion. Skull thickening and enlargement may cause headache and compression of the CRANIAL NERVES. Legs may become bowed, spinal changes may cause compression of the cord and paralysis and fractures may occur spontaneously. Paget's disease is due to an increased number, size and absorptive activity of OSTEOCLASTS. Genetic and paramyxovirus infective factors have been implicated. It is treated with pain-relieving drugs and with bisphosphonate drugs especially zoledronic acid and risedronate. (Sir James Paget, 1814–99, English surgeon).

Paget's disease

Chromic disorder of unknown cause, usually affecting middle aged and elderly people, characterized by enlarged and deformed bones. Excessive breakdown and formation of bone tissue occurs with Paget's disease and can cause bone to weaken, resulting in bone pain, arthritis, deformities, and fractures.Mentioned in: Bone X Rays, Fractures

Paget's disease

Pag·et's disease

Paget's disease

Pag′et's disease`

Paget's disease

Paget's disease

Paget's disease

Paget's disease

Paget's disease

Paget's disease

Paget disease

Paget's disease

Paget's disease

Paget's disease

Synonyms for Paget's disease

noun a disease of bone occurring in the middle aged and elderly

Synonyms

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