| 释义 |
adrenogenital syndrome
adrenogenital syndromeOversecretion of adrenal sex hormones, resulting in intense masculinizing of the body.adrenogenital syndrome
adrenogenital syndrome[ə¦drēn·ō′jen·ə·təl ′sin‚drōm] (medicine) A group of symptoms associated with hypersecretion of adrenal cortex hormones; effects vary with sex and time of development. adrenogenital syndrome
adrenogenital syndrome [ah-dre″no-jen´ĭ-t'l] a group of symptoms associated with alterations of secondary sex characters, due to abnormally increased production of androgens by the adrenal glands. The term most commonly applies to the development of masculine traits in the female or premature puberty in male children. The condition may be congenital, in which case it is due to an inherited defect of the adrenal gland, or acquired, developing as a result of a tumor or hyperplasia of the adrenals.Symptoms. Females with the congenital form may be reared as boys because of masculinization of the external genitalia. Males may show sexual precocity, with development of the reproductive organs, appearance of pubic hair, and excessive body growth in early childhood. In acquired adrenogenital syndrome there is appearance of masculine secondary sex characters in the female, and precocious puberty in the male.Treatment. When an adrenal tumor is the underlying cause of the disorder, it is removed surgically. Estrogen therapy is successful in some cases.a·dre·no·gen·i·tal syn·dromegeneric designation for a group of disorders caused by congenital adrenocortical hyperplasia characterized by masculinization of women, feminization of men, sexual ambiguity or precocious sexual development of children; representative of excessive or abnormal secretory patterns of adrenocortical steroids, especially those with androgenic or estrogenic effects.adrenogenital syndrome Congenital adrenal hyperplasia, see there. ad·re·no·gen·i·tal syn·drome (ă-drē'nō-jen'i-tal sin'drōm) Generic designation for a group of disorders caused by adrenocortical hyperplasia or malignant tumors and characterized by masculinization of women, feminization of men, or precocious sexual development of children; representative of excessive or abnormal secretory patterns of adrenocortical steroids, especially those with androgenic or estrogenic effects. adrenogenital syndrome Now called congenital adrenal hyperplasia, this condition is due to various inherited enzyme defects, such as 21-hydroxylase defect, that interfere with the production of STEROIDS by the adrenals. The low blood steroid levels causes the PITUITARY gland to send out large quantities of the adrenal stimulating hormone ACTH and this results in an abnormally high output of male sex hormones, with virilization at birth and male sexual precocity.ad·re·no·gen·i·tal syn·drome (ă-drē'nō-jen'i-tal sin'drōm) Group of disorders caused by congenital adrenocortical hyperplasia characterized by masculinization of women, feminization of men, and sexual ambiguity or precocious sexual development of children. AcronymsSeeAgsThesaurusSeesyndrome |