| 单词 | p21 |
| 释义 | p21CDKN1AA gene on chromosome 6p21.2 that encodes a cyclin-dependent kinase inhibitor, which binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, thus acting as a regulator of cell cycle progression at G1. CDKN1A expression is controlled by p53, a tumour suppressor that mediates p53-dependent cell cycle G1-phase arrest in response to various stress stimuli. CDKN1A is specifically cleaved by CASP3-like caspases, activating CDK2 and possibly also the apoptosis pathway.p21Also known as p53 protein, an anticancer protein of the class of cyclin-dependent kinase inhibitors. Cyclin-dependent kinases are enzymes that have been described by Elizabeth Finkel as ‘the engines that drive the cell-cycle past its various control checkpoints.’ Inhibition of these enzymes provides a way of controlling rapidly-reproducing cells such as cancer cells. High levels of p21 are found in ageing cells. p21 protein is dysfunctional in most human cancers. |
| 随便看 |
|
英语词典包含2567994条英英释义在线翻译词条，基本涵盖了全部常用单词的英英翻译及用法，是英语学习的有利工具。