polyarteritis nodosa

polyarteritis

[pol″e-ahr″tĕ-ri´tis] multiple sites of inflammatory and destructive lesions in the arterial system.polyarteritis nodo´sa a form of systemic necrotizing vasculitis involving the small and medium-sized arteries with signs and symptoms resulting from infarction and scarring of the affected organ system. Called also Kussmaul's disease and periarteritis nodosa.

pol·y·ar·ter·i·tis no·do·sa

segmental inflammation, with infiltration by eosinophils, and necrosis of medium-sized or small arteries, more common in males, with varied symptoms related to involvement of arteries in the kidneys, muscles, gastrointestinal tract, and heart. Synonym(s): arteritis nodosa, Kussmaul disease, periarteritis nodosa

polyarteritis nodosa

Periarteritis nodosa Internal medicine A connective tissue disease, characterized by necrotizing vasculitis of small to medium-sized arteries, affecting multiple organ systems–GI tract, kidneys, liver, muscle, skin; in > 50%, vasculitis affects peripheral nerves as mononeuritis multiplex or symmetric sensorimotor polyneuropathy Clinical Fever, malaise, myalgia Lab ↑ WBCs, ↑ ESR, 30-50% have HBsAg or HBsAb Management Immunosuppression–eg, prednisone, cyclophosphamide yields ± 90% 5-yr survival

pol·y·ar·te·ri·tis no·do·sa

(pol'ē-ahr'tĕr-ī'tis nō-dō'să) Segmental inflammation, with infiltration by eosinophils, and necrosis of medium or small arteries; most common in males, with varied symptoms related to involvement of arteries in the kidneys, muscles, gastrointestinal tract, and heart.
Synonym(s): periarteritis nodosa.

polyarteritis nodosa

An inflammatory disease of medium-sized arteries, causing nodular swellings (aneurysms) along the length of the affected vessels. The condition is due to a disturbance of the immune system sometimes triggered by the hepatitis B virus. There is loss of appetite and weight, obstruction to the blood flow causing raised blood pressure, muscle weakness and sometimes gangrene. Involvement of the CORONARY ARTERIES may cause a heart attack. Treatment is with large doses of corticosteroid drugs. Also known as periarteritis nodosa.

Kussmaul,

Adolph, German physician, 1822-1902. Kussmaul aphasia - mutism in psychosis.Kussmaul breathingKussmaul coma - Synonym(s): diabetic comaKussmaul disease - segmental inflammation, with infiltration by eosinophils, and necrosis of medium-sized or small arteries. Synonym(s): polyarteritis nodosaKussmaul paradoxical pulseKussmaul pulse - reduction or disappearance of the pulse during inspiration.Kussmaul respiration - deep, rapid respiration characteristic of diabetic or other causes of acidosis. Synonym(s): Kussmaul-Kien respirationKussmaul sign - in constrictive pericarditis, a paradoxical increase in venous distention and pressure during inspiration. Synonym(s): Kussmaul symptomKussmaul symptom - Synonym(s): Kussmaul signKussmaul-Kien respiration - Synonym(s): Kussmaul respiration

scleritis

Inflammation of the sclera, which in its severe necrotizing or in the posterior type may cause sight-threatening complications such as keratitis, uveitis, angle-closure glaucoma or optic neuropathy. It affects females more commonly than males in the fourth to sixth decades of life. Like episcleritis it has a tendency to recur. It is characterized by pain, which can be severe, redness, tearing and some patients may develop nodules (nodular scleritis). It is often associated with a systemic disease (e.g. rheumatoid arthritis, Wegener's granulomatosis, polyarteritis nodosa, lupus erythematosus, ankylosing spondylitis, syphilis, herpes zoster). It can involve part of the sclera, e.g. anterior scleritis (which is the most common, and it is classified as diffuse non-necrotizing or nodular non-necrotizing) or posterior scleritis. Treatment includes topical and systemic steroids and immunosuppressive drugs for very severe cases. See acute stromal keratitis; Brown's superior oblique tendon sheath syndrome.
necrotizing scleritis The most severe form of scleritis, much less common than the other types. About half the patients have one of the following diseases: rheumatoid arthritis, Wegener's granulomatosis, polyarteritis nodosa, systemic lupus erythematosus, or herpes zoster. It is characterized by pain, and white, avascular areas next to damaged areas through which one can see the brown colour of the underlying uveal tissue, and to congested areas of the sclera. In most cases visual acuity is decreased. The necrosis gradually spreads around the globe. Treatment typically consists of topical steroids, immunosuppressive agents and occasionally surgery to repair scleral or corneal perforation. See keratolysis; scleromalacia.
scleritis necroticans See scleromalacia.
posterior scleritis Inflammation of the sclera involving the posterior segment of the eye. The condition is often associated with a systemic disease (e.g. rheumatoid arthritis). It is characterized by pain and reduced visual acuity. The severity of the visual impairment depends on the involved tissue and its location. Signs include eyelid oedema, proptosis, limitation of ocular movements and, if anterior scleritis is present, redness. The ocular fundus may present disc swelling, choroidal folds, macular oedema and serous retinal detachment. Treatment consists mainly of systemic steroids and immunosuppressive agents. See choroidal folds.

polyarteritis nodosa

polyarteritis nodosa

polyarteritis nodosa

polyarteritis nodosa

polyarteritis

pol·y·ar·ter·i·tis no·do·sa

polyarteritis nodosa

pol·y·ar·te·ri·tis no·do·sa

polyarteritis nodosa

Kussmaul,

scleritis

polyarteritis nodosa

Synonyms for polyarteritis nodosa

noun a progressive disease of connective tissue that is characterized by nodules along arteries

Synonyms

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