SIRT1

A gene on chromosome 10q21.3 that encodes a widely expressed NAD-dependent protein deacetylase, which links transcriptional regulation to intracellular energetics and co-ordinates distinct cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. SIRT1 can modulate chromatin function by deacetylating histones and altering the methylation of histones and DNA, leading to transcriptional repression. It deacetylates a broad range of transcription factors and co-regulators, up- and downregulating target gene expression.

单词	sirt1
释义	DictionarySeesirtuin SIRT1 SIRT1 A gene on chromosome 10q21.3 that encodes a widely expressed NAD-dependent protein deacetylase, which links transcriptional regulation to intracellular energetics and co-ordinates distinct cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. SIRT1 can modulate chromatin function by deacetylating histones and altering the methylation of histones and DNA, leading to transcriptional repression. It deacetylates a broad range of transcription factors and co-regulators, up- and downregulating target gene expression.
随便看	mayer state park mwace mwacs mwacw mwad mwadb mwaf mwafcu mwag mwah mwahs mwai mwaiia mwais mwak mwal mwalimu mwalimu nyerere memorial academy mwalp mwalt mwam mwamoc mwan mwanamutapa mwana mwende child development centre