| 单词 | usp34 |
| 释义 | USP34USP34A gene on chromosome 2p15 that encodes a deubiquitinating C19 family peptidase. USP34 activates the Wnt signalling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilising AXIN1 and AXIN2, leading to their accumulation in the nucleus and upregulation of beta-catenin–CTNBB1-mediated transcription. It is also a less preferred gene symbol for what is now designated as USP35, see there. |
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