MYO7A

Notation for the gene for unconventional myosin 7A.

MYO7A

A gene on chromosome 11q13.5 that encodes a protein belonging to the myosin gene superfamily of motor proteins, which is highly expressed in the retina and cochlea. It is thought to bind to membranes that are moved relative to actin filaments. MYO7A is thought to play a role in trafficking of ribbon-synaptic vesicle complexes and renewing outer photoreceptors disks; in the inner ear, it is thought to maintain the rigidity of stereocilia during the dynamic movements of the bundle.
Molecular pathology
MYO7A’s involvement in hair-cell vesicle trafficking of aminoglycosides may explain the pathogenesis of the ototoxicity seen with aminoglycosides.

单词	myo7a
释义	MYO7A MYO7A Notation for the gene for unconventional myosin 7A. MYO7A A gene on chromosome 11q13.5 that encodes a protein belonging to the myosin gene superfamily of motor proteins, which is highly expressed in the retina and cochlea. It is thought to bind to membranes that are moved relative to actin filaments. MYO7A is thought to play a role in trafficking of ribbon-synaptic vesicle complexes and renewing outer photoreceptors disks; in the inner ear, it is thought to maintain the rigidity of stereocilia during the dynamic movements of the bundle. Molecular pathology MYO7A’s involvement in hair-cell vesicle trafficking of aminoglycosides may explain the pathogenesis of the ototoxicity seen with aminoglycosides.
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