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MoabenUK
Mo·ab M0358600 (mō′ăb)1. An ancient kingdom east of the Dead Sea in present-day southwest Jordan. According to the Bible, its inhabitants were descendants of Lot. Archaeological exploration has traced settlement in the area to at least the 13th century bc.2. A city of southeast Utah on the Colorado River. It is a center for recreation in the Canyonlands.Moab (ˈməʊæb) n (Placename) Old Testament an ancient kingdom east of the Dead Sea, in what is now the SW part of Jordan: flourished mainly from the 9th to the 6th centuries bcMo•ab (ˈmoʊ æb)
n. an ancient kingdom E of the Dead Sea, in what is now Jordan. MoabenUK
Moab (mō`ăb), ancient nation located in the uplands E of the Dead Sea, now part of Jordan. The area is unprotected from the east, hence its history is a chain of raids by the Bedouin. The Moabites were close kin to the Hebrews, and the language of the Moabite stoneMoabite stone
, ancient slab of stone erected in 850 B.C. by King Mesha of Moab; it contains a long inscription commemorating a victory in his revolt against Israel. It was discovered at Dibon, Jordan (1868), by F. A. Klein, a German clergyman.
..... Click the link for more information. is practically the same as biblical Hebrew. The relations of Moab with Judah and Israel are continually mentioned in the Bible. As a political entity, Moab came to an end after the invasion (c.733 B.C.) of Tiglathpileser IIITiglathpileser III,
d. 728 B.C., king of ancient Assyria. He seems to have usurped the throne in 745 B.C. He bore the alternative name of Pul, by which he was known in biblical history (2 Kings 15.19).
..... Click the link for more information. . Its people were later absorbed by the Nabataeans. The Moabite religion was much like that of Canaan. Archaeological exploration in Moab has shown that settlements first occurred in the 13th cent. B.C.Moab the ancient state of the Moabites, one of the tribes of Canaan. Moab is believed to have arisen in the second half of the second millennium B.C. on the east bank of the Jordan River and the shore of the Dead Sea. For several centuries Moab carried on a struggle with the states of Palestine and southern Syria. In the llth and tenth centuries B.C., Moab evidently formed part of the Kingdom of Israel and Judah. In the ninth century B.C., it became politically independent. The most prolonged wars were carried on by King Mesha (ninth century B.C.), who expanded the territory of the state significantly. In the second half of the eighth century B.C., Moab came under the control of Assyria. (Moab is repeatedly mentioned in cuneiform sources.) Of the pantheon of Moabite gods, the supreme god, Chemosh, and one of his hypostases, Ashtar-Chemosh, are well known. The Moabites wrote with the Phoenician script and were noticeably influenced by Phoenician culture. Moab Old Testament an ancient kingdom east of the Dead Sea, in what is now the SW part of Jordan: flourished mainly from the 9th to the 6th centuries bc MoAbenUK
MoAbAbbreviation for monoclonal antibody.monoclonal antibody Diagnostics
Mabs are used in diagnostics by radioactively labelling them to target malignant cells, detect metastases and screen body fluids for microorganisms, or measure levels of circulating hormones.
Fringe oncology
Alternative healthcare providers may include therapeutic Mabs as a part of treatment.
Immunology
A highly specific antibody formed by a clone of B lymphocytes, either naturally (e.g., in cold haemagglutinin) or produced synthetically by fusing an immortal cell (mouse myeloma) to a cell producing an antibody against a desired antigen.
Oncology
Mabs are increasingly used in cancer management as they directly inhibit the growth of certain tumours, can be chemically bound to toxins that are lethal to malignant cells, stimulate the complement system in destroying malignant cells, can be used to purge the BM of malignant cells, and form the basis for vaccines and drug delivery systems.
Adverse effects
Allergic reactions, fevers, chills, hypotension, liver and kidney problems.
Pathology
Mabs are used in pathology to differentiate tumour subtypes with batteries of Mabs raised against intermediate filaments or membrane antigens.antibody (ant'i-bod?e) [ anti- + body], Ab ANTIBODY: Structure of one igG moleculeA substance produced by B lymphocytes in response to a unique antigen. Each Ab molecule combines with a specific antigen to destroy or control it. All antibodies, except natural antibodies (antibodies to different blood types), are made by B cells stimulated by a foreign antigen, typically a foreign protein, polysaccharide, or nucleic acid. Synonym: immunoglobulin See: illustration; antigen; autoantibody; cytokine; isoantibodyAntibodies neutralize or destroy antigens in several ways. They can initiate lysis of the antigen by activating the complement system; neutralize toxins released by bacteria, coating (opsonizing) the antigen or forming a complex to stimulate phagocytosis; promote antigen clumping (agglutination); or prevent the antigen from adhering to host cells. An antibody molecule consists of four polypeptide chains (two light and two heavy), which are joined by disulfide bonds. The heavy chains form the complement-binding site, and the light and heavy chains form the site that binds the antigen.  ASCARIS LUMBRICOIDESacetylcholine receptor binding antibody Abbreviation: AChR-Ab
An autoantibody against acetylcholine receptors in the neuromuscular junction. Binding, blocking, or modulating antibodies against this receptor are found in the blood of most patients with generalized myasthenia gravis and in about half of all patients with ocular forms of the disease. illustrationagonistic antibodyAn antibody that stimulates or activates an organ. E.g., agonistic antibodies against the thyrotropin receptor in Grave disease stimulate the thyroid gland to release thyroid hormones that produce hyperthyroidism. anticardiolipin antibody Abbreviation: aCLa
An autoantibody against the cell membrane lipid, diphosphatidyl glycerol. It produces abnormal and sometimes life-threatening blood clotting. The antibody is found in a variety of autoimmune and infectious diseases, including in patients with the antiphospholipid antibody syndrome and syphilis. anticyclic citrullinated peptide antibody Abbreviation: anti-CCP
An antibody found in the serum of patients with rheumatoid arthritis but not in those with other joint or soft tissue diseases.anti–DNase B antibodyAn antibody formed during infection with group A beta-hemolytic streptococci. It is used, retrospectively, to help diagnose recent streptococcal infections. antiendomysial antibodyAn antibody that cross-reacts with smooth muscle collagen and the gluten in wheat, found in the serum of people with celiac sprue and some related autoimmune diseases.antiendothelial cell antibodyAn autoantibody present in the serum of patients with a variety of autoimmune diseases, including scleroderma (systemic sclerosis), systemic lupus erythematosus, interstitial lung diseases, and sarcoidosis. They attach to antigens on the cells that line blood vessels and injure those cells, producing blood vessel injury and inflammation (vasculitis). antifibrillarin antibodyAn autoantibody to the nucleolar protein fibrillarin, found in patients with diffuse systemic sclerosis (scleroderma), esp. those with relatively severe disease. It is identified more often in men than in women with the disease and in people of African descent as opposed to Europeans or Asians. antiganglioside antibodyAn antibody formed against the chemical components of nerves, found in the serum of those with Guillain-Barré syndrome.antigliadin antibodyAn antibody formed against the gluten in wheat, found in the serum of people with celiac sprue.antileukocyte antibodyAny antibody found in plasma that, when donated and infused into a recipient, damages the recipient's white blood cells. Leukocyte injury after plasma exchange or infusion is the event that triggers transfusion-related acute lung injury. anti-Hu antibodyAn autoantibody associated with paraneoplastic encephalomyelitis. It is also known as ANNA-1 (antineuronal nuclear antibody-1). antimicrosomal antibodyAn autoantibody found in the plasma of patients with thyroid injury, e.g., in several forms of thyroiditis and other rheumatologic or autoimmune diseases.anti-myeloperoxidase antibodyAn antibody found in patients with several autoimmune vasculitides, such as microscopic polyangitis. Synonym: perinuclear anti–neutrophil cytoplasmic antibodyantineuronal nuclear antibody Abbreviation: ANNA
Any of several antibodies that bind to neuronal targets in the cerebrum and cerebellum, producing paraneoplastic neurological dysfunction. The antibodies are typically released by cancers such as small-cell carcinoma of the lung (also known as ANNA-1 and ANNA-2), testicular cancer (anti-Ta antibody), or breast cancer (ANNA-2). antineutrophil cytoplasmic antibody Abbreviation: ANCA
An autoantibody found in the blood of patients with certain forms of vasculitis (such as Churg-Strauss syndrome, microscopic polyangiitis, Wegener granulomatosis) esp. when it affects small blood vessels.antinuclear antibody Abbreviation: ANA
Any of a group of autoantibodies that react against normal components of the cell nucleus. These antibodies are present in a variety of immunologic diseases, including systemic lupus erythematosus, progressive systemic sclerosis, Sjögren syndrome, scleroderma, polymyositis, and dermatomyositis, and in some patients taking hydralazine, procainamide, or isoniazid. In addition, ANA is present in some normal people. Tests for ANAs are used in the diagnosis and management of autoimmune diseases. antiphospholipid antibody Abbreviation: aPLa
Any of a group of immunoglobulin autoantibodies that react with phospholipids, which are one of the primary components of the cell membrane (the other components are glycolipids and steroids). These antibodies are found in patients with a variety of connective tissue and infectious disorders, including systemic lupus erythematosus, the antiphospholipid antibody syndrome, syphilis, and malaria. They cause abnormal blood clotting, thrombocytopenia; and in women of childbearing age, repeated miscarriages. The anticardiolipin antibodies are one type of antiphospholipid antibody. anti–proliferating cell nuclear antigen (PCNA) antibody Abbreviation: anti-PCNA
An antibody found in the blood of patients with diseases in which cells replicate rapidly. Such conditions include autoimmune and inflammatory diseases and malignancies. antiproteinase-3 antibodyAn autoantibody found in patients with small blood vessel vasculitides, such as Wegener granulomatosis. Synonym: diffusely cytoplasmic anti–neutrophil antibodyantireceptor antibodyAn antibody that reacts with the antigen receptor on a cell rather than with an antigen itself.antiribosomal P antibodyAn autoantibody found in patients with systemic lupus erythematosus, esp. those with neurological or psychiatric manifestations of the disorder.anti-scl-70 antibodyAnti-topoisomerase I antibody.antithyroperoxidase antibody Abbreviation: TPOAb
A serum marker of autoimmune thyroid destruction, i.e., of Grave disease or Hashimotothyroiditis.antititin antibodyAn antibody that reacts with striated muscle cells. It is found principally in people with myasthenia gravis who also have thymoma. anti-topoisomerase I antibodyAn autoantibody found in the serum of patients with progressive systemic sclerosis, silicosis, and systemic lupus erythematosus. Higher levels of the antibody correlate with worsening kidney, lung, and skin disease. Synonym: anti-scl-70 antibodyblocking antibodyAn antibody that prevents an antigen from binding with a cellular receptor.catalytic antibodyAbzyme.cross-reacting antibodyAn antibody that reacts with antigens other than its specific antigen because they contain binding sites that are structurally similar to its specific antigen. See: antigenic determinantcytotoxic antibodyAn antibody that lyses cells by binding to a cellular antigen and activating complement or killer cells.diffusely cytoplasmic anti-neutrophil cytoplasmic antibody Abbreviation: C-ANCA.
Antiproteinase-3 antibody.direct fluorescein-conjugated antibody Abbreviation: DFA
Direct fluorescent antibody.direct fluorescent antibody Abbreviation: DFA
A fluorescent antibody test performed on sputum to detect microorganisms that invade the respiratory tract, e.g., Legionella, Mycoplasma, or Bacillus anthracis. Synonym: direct fluorescein-conjugated antibody; direct immunofluorescence testDonath-Landsteiner antibody See: Donath-Landsteiner antibodyfluorescent antibody Abbreviation: FA
An antibody that has been stained or marked by a fluorescent material. The fluorescent antibody technique permits rapid diagnosis of various infections. glutamic acid decarboxylase antibody Abbreviation: GADA
An antibody to glutamic acid decarboxylase. It is a serum marker of type 1 diabetes mellitus and is found in the blood of patients with stiff-person syndrome. immune antibodyAn antibody produced by immunization or as a result of transfusion of incompatible blood.maternal antibodyAn antibody produced by the mother and transferred to the fetus in utero or during breastfeeding.monoclonal antibody Abbreviation: MoAB
A type of antibody, specific to a certain antigen, created in the laboratory from hybridoma cells. Because monoclonal antibodies are derived from a single cell line and raised against a single antigen, they are highly specific. Diagnostically, they are used to identify microorganisms, white blood cells, hormones, and tumor antigens. In patient care, they are used to treat transplant rejection, certain cancers, and autoimmune diseases. Hybridoma cells, used to produce monoclonal antibodies, are formed by the fusion of a spleen cell from a mouse immunized with an antigen and a multiple myeloma cell (a cancerous plasma B cell). The fused cells are screened to identify those that secrete antibodies against a specific antigen. A continuous supply of these antigen-specific monoclonal antibody secreting cells can then be grown in cultures. See: antibody; B cell; hybridomanatural antibodyAn antibody present in a person without known exposure to the specific antigen, such as an anti-A antibody in a person with B blood type.panel reactive antibody Abbreviation: PRA
A measure of an organ transplant recipient's level of sensitization to antigens on donated organs. It is the percentage of cells taken from a broad selection of blood donors against whose antigens the organ recipient's serum reacts. The higher the panel reactive antibody, the more challenging it is to match a donor organ to the recipient. perinuclear antineutrophil cytoplasmic antibodyAntimyeloperoxidase antibody.p504s antibody Alpha-methylacyl-CoA racemase.polyclonal antibodyAn antibody that reacts with many different antigens. protective antibodyAn antibody produced in response to an infectious disease. See: immunityradionuclide-linked monoclonal antibodyA monoclonal antibody to which a radioisotope has been attached. The antibody attaches to receptors on the surface of undesired cells (e.g., cancer cells) and delivers a dose of radiation directly to those cells, leaving healthy cells and tissues relatively unaffected. sensitizing antibodyReagin.toxin-linked monoclonal antibodyA monoclonal antibody to which a cell-killing drug has been attached. The antibody combines preferentially with receptors on undesired cells (such as cancer cells) and delivers its lethal drug to those cells but not to healthy cells and tissues. To increase their effectiveness and decrease immune responses to these cells, genes for antigen binding sites from human antibodies are added, creating humanized monoclonal antibodies. warm antibodyWarm autoagglutinin.illustration
monoclonal antibody Abbreviation: MoAB
A type of antibody, specific to a certain antigen, created in the laboratory from hybridoma cells. Because monoclonal antibodies are derived from a single cell line and raised against a single antigen, they are highly specific. Diagnostically, they are used to identify microorganisms, white blood cells, hormones, and tumor antigens. In patient care, they are used to treat transplant rejection, certain cancers, and autoimmune diseases. Hybridoma cells, used to produce monoclonal antibodies, are formed by the fusion of a spleen cell from a mouse immunized with an antigen and a multiple myeloma cell (a cancerous plasma B cell). The fused cells are screened to identify those that secrete antibodies against a specific antigen. A continuous supply of these antigen-specific monoclonal antibody secreting cells can then be grown in cultures. See: antibody; B cell; hybridomaSee also: antibodyMOAB
| Acronym | Definition |
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| MOAB➣Massive Ordnance Air Blast (US DoD munition) | | MOAB➣Monoclonal Antibody | | MOAB➣Mother of All Bombs (slang for the MOAB weapon) | | MOAB➣Month of Apple Bugs (Mac security problems) | | MOAB➣Management of Aggressive Behavior (NANA) | | MOAB➣Mother of All Battles | | MOAB➣Mother of All Bailouts (humor) | | MOAB➣Marketing Order Administration Branch | | MOAB➣Mother of All Bloons | | MOAB➣Mother Of All Buffets | | MOAB➣Massive Ornary Air Blimp (gaming; Bloons Tower Defense 3) | | MOAB➣Mother of All Blowers (Automotive Supercharger) | | MOAB➣Microsoft Application Bridge | | MOAB➣Motorised Air-Break (type of switch used in electricity distribution systems) |
ThesaurusSeemonoclonal antibody |