myelomatosis, multiple myeloma

A malignant disorder of antibody-producing PLASMA CELLS. Plasma cells derive from a single selected B lymphocyte and produce a single monoclonal antibody (immunoglobulin). In myelomatosis, large quantities of monoclonal immunoglobulin are produced as a kind of cancer in the bone marrow that progressively replaces the blood-forming tissue and absorbs bone causing areas of OSTEOPOROSIS. There is widespread bone pain and crippling spontaneous fractures and the effects of anaemia and thickening of the blood from excessive globulins. This may affect brain function. The urine may contain considerable quantities of immunoglobulin (Bence Jones protein). Treatment is with anticancer drugs such as MELPHALAN, with total body irradiation followed by restoration of the bone marrow with autologous haematopoietic stem cells. In relapsing cases the proteasome inhibitor drug BORTEZOMIB has proved more effective than THALIDOMIDE with DEXAMETHASONE.

单词	myelomatosis, multiple myeloma
释义	myelomatosis, multiple myeloma myelomatosis, multiple myeloma A malignant disorder of antibody-producing PLASMA CELLS. Plasma cells derive from a single selected B lymphocyte and produce a single monoclonal antibody (immunoglobulin). In myelomatosis, large quantities of monoclonal immunoglobulin are produced as a kind of cancer in the bone marrow that progressively replaces the blood-forming tissue and absorbs bone causing areas of OSTEOPOROSIS. There is widespread bone pain and crippling spontaneous fractures and the effects of anaemia and thickening of the blood from excessive globulins. This may affect brain function. The urine may contain considerable quantities of immunoglobulin (Bence Jones protein). Treatment is with anticancer drugs such as MELPHALAN, with total body irradiation followed by restoration of the bone marrow with autologous haematopoietic stem cells. In relapsing cases the proteasome inhibitor drug BORTEZOMIB has proved more effective than THALIDOMIDE with DEXAMETHASONE.
随便看	efedrine efee efees efef efeh efei efeito posterior duradouro de treinamento efej efek beragun aset efel efela efem efemp efemp1 efemp2 efena efence efendi deficiency report deficiency reporting log system deficiency reporting system deficiency review board deficiency symptom deficiency tracking system deficiency trend analysis & reporting