occult primary malignancy

Occult cancer, unknown primary A malignancy of unknown 1º site or origin that is symptomless, which first manifests itself as metastases or secondary–paraneoplastic phenomena, and usually has a poor prognosis; OPMs are problematic as appropriate therapy requires that the primary malignancy be eradicated, and many remain obscure despite aggressive diagnostic work-up; certain malignancies metastasize to certain sites with greater than expected frequency; in OPMs affecting the brain, the primary arises in the lungs in up to 85% Treatment Up to 30% of Pts with metastases from an occult primary adenoCA may respond to chemotherapy–mitomycin C, adriamycin, vincristine; poor response is more common in ♂ and in Pts with liver and/or infradiaphragmatic metastases Occult primary malignancies Bone Breast, bronchus, prostate, thyroid, kidney CNS Breast, bronchus, kidney, colon Head & neck Oropharynx, nasopharynx–most are squamous cell carcinoma; also adenocarcinoma, melanoma, rhabdomyosarcoma, oat cell, salivary gland, thyroid carcinomas Liver CA of stomach, colon, breast, pancreas, or bronchus Lung Breast, colon, kidney, melanoma, sarcoma, stomach, testis, thyroid Lymph nodes • Cervix Naso– and oropharynx, thyroid, larynx, lymphoma • Supraclavicular Bronchi, breast, stomach, esophagus, pancreas, colorectal,
lymphoma • Axillary Breast, melanoma, lymphoma • Inguinal Urogenital tract, anus, melanoma, lymphoma Ovary Stomach, colon Serosal surfaces Bronchi, breast, ovary, lymphoma Skin Melanoma, breast, bronchus, stomach, kidney

单词	occult primary malignancy
释义	DictionarySeeskinEncyclopediaSeebone occult primary malignancy occult primary malignancy Occult cancer, unknown primary A malignancy of unknown 1º site or origin that is symptomless, which first manifests itself as metastases or secondary–paraneoplastic phenomena, and usually has a poor prognosis; OPMs are problematic as appropriate therapy requires that the primary malignancy be eradicated, and many remain obscure despite aggressive diagnostic work-up; certain malignancies metastasize to certain sites with greater than expected frequency; in OPMs affecting the brain, the primary arises in the lungs in up to 85% Treatment Up to 30% of Pts with metastases from an occult primary adenoCA may respond to chemotherapy–mitomycin C, adriamycin, vincristine; poor response is more common in ♂ and in Pts with liver and/or infradiaphragmatic metastases Occult primary malignancies Bone Breast, bronchus, prostate, thyroid, kidney CNS Breast, bronchus, kidney, colon Head & neck Oropharynx, nasopharynx–most are squamous cell carcinoma; also adenocarcinoma, melanoma, rhabdomyosarcoma, oat cell, salivary gland, thyroid carcinomas Liver CA of stomach, colon, breast, pancreas, or bronchus Lung Breast, colon, kidney, melanoma, sarcoma, stomach, testis, thyroid Lymph nodes • Cervix Naso– and oropharynx, thyroid, larynx, lymphoma • Supraclavicular Bronchi, breast, stomach, esophagus, pancreas, colorectal, lymphoma • Axillary Breast, melanoma, lymphoma • Inguinal Urogenital tract, anus, melanoma, lymphoma Ovary Stomach, colon Serosal surfaces Bronchi, breast, ovary, lymphoma Skin Melanoma, breast, bronchus, stomach, kidney FinancialSeeSkin
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