| 释义 |
Michaelis-Menten hypothesis Mi·chae·lis-Men·ten hy·poth·e·sis (mi-kā'lis men'tĕn), a hypothesis that a complex is formed between an enzyme and its substrate (also known as the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (also referred to as the Brown hypothesis), the latter step being the rate-determining step for the overall rate of substrate-product conversion.
See also: Michaelis-Menten constant, Michaelis-Menten equation. [Leonor Michaelis, Maud L. Menten] Mi·chae·lis-Men·ten hy·poth·e·sis (mi-kā'lis-men'tĕn hī-poth'ĕ-sis) That a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion. [Leonor Michaelis, Maud L. Menten]Menten, Maud Leonora, Canadian pathologist in U.S., 1879-1960. Michaelis-Menten constant - Synonym(s): Michaelis constantMichaelis-Menten equation - see under MichaelisMichaelis-Menten hypothesis - see under MichaelisVictor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation
Michaelis, Leonor, German-U.S. chemist and physician, 1875-1949. Michaelis bufferMichaelis constant - the true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction. Synonym(s): Michaelis-Menten constantMichaelis-Gutmann body - a rounded homogenous body containing calcium and iron found within macrophages in the bladder wall in malacoplakia.Michaelis-Menten constant - Synonym(s): Michaelis constantMichaelis-Menten equation - an initial-rate equation for a single-substrate noncooperative enzyme-catalyzed reaction relating the initial velocity to the initial substrate concentration. Synonym(s): Victor-Michaelis-Menten equationMichaelis-Menten hypothesis - that a complex is formed between an enzyme and its substrate (the O'Sullivan-Tompson hypothesis), which complex then decomposes to yield free enzyme and the reaction products (Brown hypothesis), the latter rate determining the overall rate of substrate-product conversion.Victor-Michaelis-Menten equation - Synonym(s): Michaelis-Menten equation |